Reference : Hair cell progenitors: identification and regulatory genes
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/29256
Hair cell progenitors: identification and regulatory genes
English
Bodson, Morgan [Université de Liège - ULg > > Physiologie humaine et physiopathologie >]
Breuskin, Ingrid mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie >]
Jul-2009
Acta Oto-Laryngologica
Taylor & Francis
10
1-6
Yes (verified by ORBi)
International
0001-6489
Oslo
Norway
[en] inner ear ; cochlea ; development ; regeneration ; hair cells
[en] Hair cell loss in higher vertebrates appears to be permanent. Progenitors that are quiescent in the organ of Corti are the best candidates for the restoration of the different cell types in the organ of Corti. However, little is known about the presence of these progenitors and their capacity to differentiate into hair cells. This review will first highlight recent findings concerning the identification of progenitor cells that are able to proliferate and to differentiate into hair cells. Principal factors impinging on this process are then reviewed. Auditory hair cell progenitors have been identified and, under appropriate conditions, are capable of proliferating and differentiating into hair cells. Characterization of signals that maintain, expand and regulate these progenitors will be essential for the biomedical application of stem cell populations to restore hearing.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers
http://hdl.handle.net/2268/29256

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
acta otolaryngologica (2009) - bodson.pdfPublisher postprint81.5 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.