Article (Scientific journals)
Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear
Sacheli, Rosalie; Nguyen, Laurent; Borgs, Laurence et al.
2009In Gene Expression Patterns
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Keywords :
inner ear; mirna; development; mammals; cochlea; hair cells
Abstract :
[en] MicroRNAs (miRNAs) constitute a class of small non-coding endogenous RNAs that downregulate gene expression by binding to 3' untranslated region (UTR) of target messenger RNAs. Although they have been found to regulate developmental and physiological processes in several organs and tissues, their role in the regulation of the inner ear transcriptome remains unknown. In this report, we have performed systematic in situ hybridization to analyze the temporal and spatial distribution of three miRNAs (miR-96, mR-182, and mR-183) that are likely to arise from a single precursor RNA during the development and the maturation of the cochlea. Strikingly we found that the expression of mR-96, mR-182 and mR-183 was highly dynamic during the development of the cochlea, from the patterning to the differentiation of the main cochlear structures.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Sacheli, Rosalie  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Borgs, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Vandenbosch, Renaud  ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Bodson, Morgan ;  Université de Liège - ULiège > Physiologie humaine et physiopathologie
Lefèbvre, Philippe ;  Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Malgrange, Brigitte  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie
Language :
English
Title :
Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear
Publication date :
June 2009
Journal title :
Gene Expression Patterns
ISSN :
1567-133X
Publisher :
Elsevier Science, Amsterdam, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
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