Reference : Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/29255
Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear
English
Sacheli, Rosalie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Borgs, Laurence mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Vandenbosch, Renaud mailto [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Bodson, Morgan [Université de Liège - ULg > > Physiologie humaine et physiopathologie >]
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie >]
Jun-2009
Gene Expression Patterns
Elsevier Science
Yes (verified by ORBi)
International
1567-133X
Amsterdam
The Netherlands
[en] inner ear ; mirna ; development ; mammals ; cochlea ; hair cells
[en] MicroRNAs (miRNAs) constitute a class of small non-coding endogenous RNAs that downregulate gene expression by binding to 3' untranslated region (UTR) of target messenger RNAs. Although they have been found to regulate developmental and physiological processes in several organs and tissues, their role in the regulation of the inner ear transcriptome remains unknown. In this report, we have performed systematic in situ hybridization to analyze the temporal and spatial distribution of three miRNAs (miR-96, mR-182, and mR-183) that are likely to arise from a single precursor RNA during the development and the maturation of the cochlea. Strikingly we found that the expression of mR-96, mR-182 and mR-183 was highly dynamic during the development of the cochlea, from the patterning to the differentiation of the main cochlear structures.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers
http://hdl.handle.net/2268/29255

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