Article (Scientific journals)
HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Michiels, C.; Minet, E.; Michel, G. et al.
2001In IUBMB Life, 52 (1-2), p. 49-53
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Keywords :
Animals; Anoxia/enzymology/genetics; DNA-Binding Proteins/metabolism; Endothelial Growth Factors/biosynthesis/genetics; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphokines/biosynthesis/genetics; Mitogen-Activated Protein Kinases/metabolism; Nuclear Proteins/metabolism; Transcription Factor AP-1/metabolism; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
Abstract :
[en] HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Michiels, C.
Minet, E.
Michel, G.
Mottet, Denis ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases
Piret, J. P.
Raes, M.
Language :
English
Title :
HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Publication date :
2001
Journal title :
IUBMB Life
ISSN :
1521-6543
eISSN :
1521-6551
Publisher :
Taylor & Francis Ltd
Volume :
52
Issue :
1-2
Pages :
49-53
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
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