ORBi: Michiels C. - HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.

Reference : HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/29242

Title :	HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Language :	English
Author, co-author :	Michiels, C. [> > > >]
	Minet, E. [> > > >]
	Michel, G. [> > > >]
	Mottet, Denis [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
	Piret, J. P. [ > > ]
	Raes, M. [> > > >]
Publication date :	2001
Journal title :	IUBMB Life
Publisher :	Taylor & Francis Ltd
Volume :	52
Issue/season :	1-2
Pages :	49-53
Audience :	International
ISSN :	1521-6543
e-ISSN :	1521-6551
Keywords :	[en] Animals ; Anoxia/enzymology/genetics ; DNA-Binding Proteins/metabolism ; Endothelial Growth Factors/biosynthesis/genetics ; Gene Expression Regulation ; Humans ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Lymphokines/biosynthesis/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Nuclear Proteins/metabolism ; Transcription Factor AP-1/metabolism ; Transcription Factors ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
Abstract :	[en] HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la Recherche dans l'Industrie et l'Agriculture ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Permalink :	http://hdl.handle.net/2268/29242
DOI :	10.1080/15216540252774766

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