ORBi: Smith G. L. - Vaccinia virus immune evasion

Reference : Vaccinia virus immune evasion


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/29199

Title :	Vaccinia virus immune evasion
Language :	English
Author, co-author :	Smith, G. L. [ > > ]
	Symons, J. A. [ > > ]
	Khanna, A. [ > > ]
	Vanderplasschen, Alain [Université de Liège - ULg > > Immunologie et vaccinologie >]
	Alcami, A. [ > > ]
Publication date :	1997
Journal title :	Immunological Reviews
Publisher :	Munksgaard International Publishers
Volume :	159
Pages :	137-154
Audience :	International
ISSN :	0105-2896
e-ISSN :	1600-065X
City :	Copenhagen
Country :	Denmark
Abstract :	[en] Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/29199

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