ORBi: Dewals Benjamin G - Evolution of Bovine herpesvirus 4: recombination and transmission between African buffalo and cattle

Reference : Evolution of Bovine herpesvirus 4: recombination and transmission between African buffal...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biotechnology Human health sciences : Immunology & infectious disease Life sciences : Microbiology
	To cite this reference:	http://hdl.handle.net/2268/29138

Title :	Evolution of Bovine herpesvirus 4: recombination and transmission between African buffalo and cattle
Language :	English
Author, co-author :	Dewals, Benjamin G [Université de Liège - ULg > > Immunologie et vaccinologie >]
	Thirion, Muriel [Université de Liège - ULg > > Immunologie et vaccinologie >]
	Markine-Goriaynoff, N. [> > > >]
	Gillet, Laurent [Université de Liège - ULg > > Immunologie et vaccinologie >]
	de Fays, K. [> > > >]
	Minner, F. [> > > >]
	Daix, V. [> > > >]
	Sharp, P. M. [> > > >]
	Vanderplasschen, Alain [Université de Liège - ULg > > Immunologie et vaccinologie >]
Publication date :	2006
Journal title :	Journal of General Virology
Publisher :	Soc General Microbiology
Volume :	87
Issue/season :	Pt 6
Pages :	1509-1519
Audience :	International
ISSN :	0022-1317
City :	Reading
Abstract :	[en] Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle throughout the world, but virological and serological studies have suggested that the African buffalo is also a natural host for this virus. It has previously been found that the Bo17 gene of BoHV-4 was acquired from an ancestor of the African buffalo, probably around 1.5 million years ago. Analysis of the variation of the Bo17 gene sequence among BoHV-4 strains suggested a relatively ancient transmission of BoHV-4 from the buffalo to the Bos primigenius lineage, followed by a host-dependent split between zebu and taurine BoHV-4 strains. In the present study, the evolutionary history of BoHV-4 was investigated by analysis of five gene sequences from each of nine strains representative of the viral species: three isolated from African buffalo in Kenya and six from cattle from Europe, North America and India. No two gene sequences had the same evolutionary tree, indicating that recombination has occurred between divergent lineages; six recombination events were delineated for these sequences. Nevertheless, exchange has been infrequent enough that a clonal evolutionary history of the strains could be discerned, upon which the recombination events were superimposed. The dates of divergence among BoHV-4 lineages were estimated from synonymous nucleotide-substitution rates. The inferred evolutionary history suggests that African buffalo were the original natural reservoir of BoHV-4 and that there have been at least three independent transmissions from buffalo to cattle, probably via intermediate hosts and - at least in the case of North American strains - within the last 500 years.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/29138
DOI :	10.1099/vir.0.81757-0

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