Reference : Re-evaluation of the site of transcription in Ehrlich tumour cell nucleoli.
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Re-evaluation of the site of transcription in Ehrlich tumour cell nucleoli.
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Lepoint, A. [> > > >]
Goessens, Guy mailto [Université de Liège - ULg > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >]
Biology of the Cell
Portland Press
Yes (verified by ORBi)
United Kingdom
[en] Animals ; Carcinoma, Ehrlich Tumor/genetics/metabolism/ultrastructure ; Cell Nucleolus/metabolism/ultrastructure ; Cells, Cultured ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron ; RNA, Neoplasm/metabolism ; Staining and Labeling ; Transcription, Genetic
[en] Recent electron microscopic immunolocalization studies (Scheer and Rose, 1984) indicated that RNA polymerase I is located in, and probably confined to, the fibrillar centres of the nucleoli. This conclusion appears to be in contradiction to previous autoradiographic studies reporting that transcription of rRNA genes takes place in the dense fibrillar component. Despite the fact that rRNA transcription occurs in the dense fibrillar component of Ehrlich tumour cell nucleoli, we show in the present paper that dense fibrillar component containing rapidly labelled RNA can be visualized not only around but also inside the fibrillar centres.

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