Reference : Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement p...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/29072
Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins.
English
Daix, Virginie [Université de Liège - ULg > > Immunologie et vaccinologie >]
Schroeder, Hélène mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Praet, N. [Université de Liège - ULg > > Immunologie et vaccinologie >]
Georgin, J.-P. [Université de Liège - ULg > > Immunologie et vaccinologie >]
Chiappino, I. [Université de Liège - ULg > > Immunologie et vaccinologie >]
Gillet, Laurent mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
de Fays, K. [Université de Liège - ULg > > Immunologie et vaccinologie >]
Decrem, Y. [> > > >]
Leboulle, G. [> > > >]
Godfroid, E. [> > > >]
Bollen, A. [> > > >]
Pastoret, Paul-Pierre mailto [> > > >]
Gern, L. [> > > >]
Sharp, P. M. [> > > >]
Vanderplasschen, Alain mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
2007
Insect Molecular Biology
Blackwell Publishing
16
2
155-66
Yes (verified by ORBi)
International
0962-1075
1365-2583
Oxford
United Kingdom
[en] Amino Acid Sequence ; Animals ; Complement Inactivator Proteins/chemistry/genetics/metabolism ; Evolution ; Female ; Immunohistochemistry ; Ixodes/chemistry/genetics/metabolism ; Molecular Sequence Data ; Multigene Family ; Salivary Glands/metabolism ; Salivary Proteins and Peptides/chemistry ; Sequence Homology, Amino Acid
[en] The alternative pathway of complement is an important innate defence against pathogens including ticks. This component of the immune system has selected for pathogens that have evolved countermeasures. Recently, a salivary protein able to inhibit the alternative pathway was cloned from the American tick Ixodes scapularis (Valenzuela et al., 2000; J. Biol. Chem. 275, 18717-18723). Here, we isolated two different sequences, similar to Isac, from the transcriptome of I. ricinus salivary glands. Expression of these sequences revealed that they both encode secreted proteins able to inhibit the complement alternative pathway. These proteins, called I. ricinus anticomplement (IRAC) protein I and II, are coexpressed constitutively in I. ricinus salivary glands and are upregulated during blood feeding. Also, we demonstrated that they are the products of different genes and not of alleles of the same locus. Finally, phylogenetic analyses demonstrate that ticks belonging to the Ixodes ricinus complex encode a family of relatively small anticomplement molecules undergoing diversification by positive Darwinian selection.
Researchers ; Professionals
http://hdl.handle.net/2268/29072
10.1111/j.1365-2583.2006.00710.x

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
fulltext.pdfAuthor postprint1.45 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.