Article (Scientific journals)
The paralogous salivary anti-complement proteins IRAC I and IRAC II encoded by Ixodes ricinus ticks have broad and complementary inhibitory activities against the complement of different host species.
Schroeder, Hélène; Daix, Virginie; Gillet, Laurent et al.
2007In Microbes and Infection, 9 (2), p. 247-50
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Keywords :
Animals; Birds; Complement Inactivator Proteins/metabolism; Complement Pathway, Alternative; Complement System Proteins/immunology; Humans; Ixodes/metabolism/pathogenicity; Mammals; Species Specificity
Abstract :
[en] Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phylogenetic analyses suggested that these sequences were diversifying by a process of positive Darwinian selection, possibly leading to molecules with different biological properties. In the present study, we tested the hypothesis that each paralogue may have different inhibitory activities against the complement of different natural host species, thereby contributing to broaden the host range of I. ricinus ticks. IRAC I and IRAC II were tested against the complement of eight I. ricinus natural host species (six mammals and two birds). The results demonstrate that IRAC I and IRAC II have broad and complementary inhibition activities against the complement of different host species. This report is the first description of paralogous anti-complement molecules encoded by a pathogen with broad and complementary inhibitory activities against the complement of different host species.
Disciplines :
Veterinary medicine & animal health
Immunology & infectious disease
Author, co-author :
Schroeder, Hélène ;  Université de Liège - ULiège > Immunologie et vaccinologie
Daix, Virginie 
Gillet, Laurent  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Renauld, Jean-Christophe
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
The paralogous salivary anti-complement proteins IRAC I and IRAC II encoded by Ixodes ricinus ticks have broad and complementary inhibitory activities against the complement of different host species.
Publication date :
2007
Journal title :
Microbes and Infection
ISSN :
1286-4579
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
9
Issue :
2
Pages :
247-50
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2009

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