Reference : Lung interstitial macrophages alter dendritic cell functions to prevent airway allerg...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/29064
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
English
Bedoret, Denis [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Wallemacq, Hugues [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Marichal, Thomas mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Desmet, Christophe mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Quesada Calvo, Florence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Henry, E. [Université Libre de Bruxelles - ULB > > > > > >]
Closset, Rodrigue [Université de Liège - ULG > > > >]
Dewals, Benjamin G mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Thielen, Caroline [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Gustin, Pascal mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
de Leval, Laurence mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Van Rooijen, N. [Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands. > > > > > >]
Le Moine, A. [Université Libre de Bruxelles - ULB > > > > > >]
Vanderplasschen, Alain mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Cataldo, Didier mailto [Université de Liège - ULg and CHU > Laboratory of Biology of Tumors and Development, GIGA-Research > > >]
Drion, Pierre mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Moser, M. [Université Libre de Bruxelles - ULB > > > > > >]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
2009
Journal of Clinical Investigation
American Society for Clinical Investigation
119
12
3723-38
Yes (verified by ORBi)
International
0021-9738
Ann Arbor
MI
[en] Lung ; interstitial macrophages ; dendritic cell ; allergy ; mice
[en] The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne LPS can induce a lung DC-driven Th2 cell response to harmless inhaled antigens, thereby promoting allergic asthma. However, only a small fraction of people exposed to environmental LPS develop allergic asthma. What prevents most people from mounting a lung DC-driven Th2 response upon exposure to LPS is not understood. Here we have shown that lung interstitial macrophages (IMs), a cell population with no previously described in vivo function, prevent induction of a Th2 response in mice challenged with LPS and an experimental harmless airborne antigen. IMs, but not alveolar macrophages, were found to produce high levels of IL-10 and to inhibit LPS-induced maturation and migration of DCs loaded with the experimental harmless airborne antigen in an IL-10-dependent manner. We further demonstrated that specific in vivo elimination of IMs led to overt asthmatic reactions to innocuous airborne antigens inhaled with low doses of LPS. This study has revealed a crucial role for IMs in maintaining immune homeostasis in the respiratory tract and provides an explanation for the paradox that although airborne LPS has the ability to promote the induction of Th2 responses by lung DCs, it does not provoke airway allergy under normal conditions.
Researchers ; Professionals
http://hdl.handle.net/2268/29064
10.1172/JCI39717

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