Reference : Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Michiels, Carine [> > > >]
Minet, Emmanuel [> > > >]
Mottet, Denis mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
Raes, Martine [> > > >]
Free Radical Biology & Medicine
Elsevier Science
Yes (verified by ORBi)
[en] Animals ; Anoxia/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Hyperoxia/genetics/metabolism ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Models, Biological ; NF-kappa B/genetics/metabolism ; Nuclear Proteins/genetics/metabolism ; Oxygen/pharmacology ; Reactive Oxygen Species/metabolism/pharmacology ; Transcription Factors
[en] Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la Recherche dans l'Industrie et l'Agriculture, Belgique

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