Reference : Unexpected Influence of Ionic Strength on Branched-Pathway Interactions between Beta-...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/28935
Unexpected Influence of Ionic Strength on Branched-Pathway Interactions between Beta-Lactamases and Beta-Halogenopenicillanates
English
De Meester, F. [Université de Liège - ULG > > Laboratoires de Microbiologie et d'Enzymologie > >]
Matagne, André mailto [Université de Liège - ULg > > Laboratoires de Microbiologie et d'Enzymologie > >]
Dive, Georges mailto [Université de Liège - ULg > > Laboratoires de Microbiologie et d'Enzymologie > >]
Frère, Jean-Marie mailto [Université de Liège - ULg > > Laboratoires de Microbiologie et d'Enzymologie > >]
1-Jan-1989
Biochemical Journal
257
1
245-9
Yes (verified by ORBi)
International
0264-6021
[en] Ionic strength strongly influenced the turnover/inactivation ratio in the interaction between beta-halogenopenicillanates and some class A beta-lactamases. This suggested the stabilization of a highly charged intermediate by solvation. Those data could be interpreted on the basis of a reaction pathway where an episulphonium ion was transiently formed. The various mechanisms proposed for explaining the formation of the dihydrothiazine chromophore are discussed.
http://hdl.handle.net/2268/28935

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