Article (Scientific journals)
Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies
Matagne, André; Lamotte-Brasseur, Josette; Frère, Jean-Marie
1993In European Journal of Biochemistry, 217 (1), p. 61-67
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Keywords :
bêta-lactamases; enzyme kinetics; inhibitors; inactivators; imipenem; monobactams
Abstract :
[en] The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were significantly hydrolysed by the enzymes. The results obtained with the Streptomyces albus G beta-lactamase have been analysed in the light of molecular modelling studies. The discussion is extended to include other so-called beta-lactamase-stable antibiotics to demonstrate that this appellation can often be misleading.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Matagne, André  ;  Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Lamotte-Brasseur, Josette ;  Université de Liège - ULiège > Centre d'Ingénierie des Protéines
Frère, Jean-Marie ;  Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
Language :
English
Title :
Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies
Publication date :
01 October 1993
Journal title :
European Journal of Biochemistry
ISSN :
0014-2956
eISSN :
1432-1033
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
217
Issue :
1
Pages :
61-67
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 November 2009

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