[en] The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were significantly hydrolysed by the enzymes. The results obtained with the Streptomyces albus G beta-lactamase have been analysed in the light of molecular modelling studies. The discussion is extended to include other so-called beta-lactamase-stable antibiotics to demonstrate that this appellation can often be misleading.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Matagne, André ; Université de Liège - ULiège > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines
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