Reference : Diversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/28922
Diversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics
English
Frère, Jean-Marie mailto [Université de Liège - ULg > > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines > >]
Joris, Bernard mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Granier, B. [Université de Liège - ULG > > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines > >]
Matagne, André mailto [Université de Liège - ULg > > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines > >]
Ackerman, Francine [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Bourguignon-Bellefroid, C. [Université de Liège - ULG > > Laboratoire d'Enzymologie, Centre d'Ingénierie des Protéines > >]
1991
Research in Microbiology
142
6, Jul-Aug
705-10
Yes (verified by ORBi)
International
0923-2508
[en] The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and properties of the beta-lactamase(s) and the diffusion barrier that the outer-membrane of Gram-negative bacteria can represent. Those three factors can be modified by mutations or by the horizontal transfer of genes or portions of genes.
http://hdl.handle.net/2268/28922

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