Reference : The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecu...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/2877
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (T-FH) cells
English
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Rickman, David [> > > >]
Thielen, Caroline mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
de Reynies, Aurélien [> > > >]
Huang, Yen-Lin [> > > >]
Delsol, Georges [> > > >]
Lamant, Laurence [> > > >]
Leroy, Karen [> > > >]
Briere, Josette [> > > >]
Molina, Thierry [> > > >]
Berger, Françoise [> > > >]
Gisselbrecht, Christian [> > > >]
Xerri, Luc [> > > >]
Gaulard, Philippe [> > > >]
1-Jun-2007
Blood
Amer Soc Hematology
109
11
4952-4963
Yes (verified by ORBi)
International
0006-4971
Washington
[en] The molecular alterations underlying the pathogenesis of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-u) are largely unknown. In order to characterize the ontogeny and molecular differences between both entities, a series of AITLs (n = 18) and PTCLs-u (n = 16) was analyzed using gene expression profiling. Unsupervised clustering correlated with the pathological classification and with CD30 expression in PTCL-u. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell- and follicular dendritic cell-related genes, chemokines, and genes related to extracellular matrix and vascular biology), and overexpression of several genes characteristic of normal follicular helper T (T-FH) cells (CXCL13, BCL6, PDCD1, CD40L, NFATC1). By gene set enrichment analysis, the AITL molecular signature was significantly enriched in published T-FH-specific genes. The enrichment was higher for sorted AITL cells than for tissue samples. Overexpression of several T-FH genes was validated by immunohistochemistry in AITLs. A few cases with molecular T-FH-like features were identified among CD30(-) PTCLs-u. Our findings strongly support that TFH cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30(-) PTCLs-u may derive from or be related to AITL.
Giga-Cancer ; Giga-Infection, Immunity and Inflammation
Fondation contre le Cancer ; fonds Leon Fredericq ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/2877
10.1182/blood-2006-10-055145

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