Reference : Perspective taking to assess self-personality: What's modified in Alzheimer's disease?
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/28746
Perspective taking to assess self-personality: What's modified in Alzheimer's disease?
English
Ruby, Perrine [Institut National de la Santé et de la Recherche Médicale - INSERM > ULg - Centre de Recherches du Cyclotron > > >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives >]
D'Argembeau, Arnaud mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Peters, Frédéric [Université de Liège - ULG > Centre de Recherches du Cyclotron > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Balteau, Evelyne mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Centre de recherches du cyclotron > Chimie organique de synthèse > >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cliniques-Neuroimagerie des troubles de la mémoire et révalid. cogn. > >]
2009
Neurobiology of Aging
Elsevier
30
10
1637-1651
Yes (verified by ORBi)
International
0197-4580
1558-1497
New York
NY
[en] self ; perspective ; Alzheimer ; anosognosia ; personality ; fMRI
[en] Personality changes are frequently described by caregivers of patients with Alzheimer's disease, while they are less often reported by the patients. This relative anosognosia of Alzheimer disease (AD) patients for personality changes might be related to impaired self-judgment and to decreased ability to understand their caregiver's perspective. To investigate this issue, we explored the cerebral correlates of self-assessment and perspective taking in patients with mild AD, elderly and young volunteers. All subjects assessed relevance of personality traits adjectives for self and a relative, taking either their own or their relative's perspective, during a functional imaging experiment. The comparison of subject's and relative's answers provided congruency scores used to assess self-judgment and perspective taking performance. The self-judgment "accuracy" score was diminished in AD, and when patients assessed adjectives for self-relevance, they predominantly activated bilateral intraparietal sulci (IPS). Previous studies associated IPS activation with familiarity judgment, which AD patients would use more than recollection when retrieving information to assess self-personality. When taking a third-person perspective, patients activated prefrontal regions (similarly to young volunteers), while elderly controls recruited visual associative areas (also activated by young volunteers). This suggests that mild AD patients relied more on reasoning processes than on visual imagery of autobiographical memories to take their relative's perspective. This strategy may help AD patients to cope with episodic memory impairment even if it does not prevent them from making some mind-reading errors.
Centre de Recherches du Cyclotron - CRC
IUAP P6/29; FNRS; EC-FP6-project DiMI, LSHB-CT-2005-512146; EC Marie Curie fellowship
http://hdl.handle.net/2268/28746
also: http://hdl.handle.net/2268/33436
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18258337

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