|Reference : Quantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electro...|
|Scientific journals : Article|
|Physical, chemical, mathematical & earth Sciences : Chemistry|
|Quantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis|
|Bechet, Isabelle [Université de Liège - ULG > Pharmacie > Analyse des Médicaments > >]|
|Hubert, Philippe [Université de Liège - ULg > Département de Pharmacie > Chimie analytique > > >]|
|Crommen, Jacques [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]|
|Fillet, Marianne [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]|
|Journal of Pharmaceutical & Biomedical Analysis|
|[en] The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%.|
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