Reference : Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/2851
Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes
English
Huber, Christoph [University Hospital of Zurich > Insitute of Neuropathology > > >]
Thielen, Caroline mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie Humaine > >]
Seeger, Harald [University Hospital of Zurich > Insitute of Neuropathology > > > >]
Schwarz, Petra [University Hospital of Zurich > Insitute of Neuropathology > > > >]
Montrasio, Fabio [University Hospital of Zurich > Insitute of Neuropathology > > > >]
Wilson, Mark [> > > >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Fu, Yang-Xin [> > > >]
Miele, Gino [University Hospital of Zurich > Insitute of Neuropathology > > > >]
Aguzzi, Adriano [University Hospital of Zurich > Insitute of Neuropathology > > > >]
1-May-2005
Journal of Immunology
Amer Assoc Immunologists
174
9
5526-5536
Yes (verified by ORBi)
International
0022-1767
Bethesda
[en] Affinity-maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT beta receptor (LT beta R) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expression analysis of 3 of 12 genes both enriched in FDCs and down-regulated by LT beta R signaling suppression validated them as FDC markers. Functional analysis of one of these three, clusterin, suggests a role as an FDC-derived trophic factor for GC B cells. Hence, the set of genes presented in this study includes markers emanating from LT beta R signaling and transcripts relevant to GC and FDC function.
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
http://hdl.handle.net/2268/2851

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