Reference : Central and Peripheral Metabolism of 5 Alpha-Dihydrotestosterone in the Male Japanese Qu...
Scientific journals : Article
Life sciences : Zoology
Human health sciences : Endocrinology, metabolism & nutrition
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/28494
Central and Peripheral Metabolism of 5 Alpha-Dihydrotestosterone in the Male Japanese Quail: Biochemical Characterization and Relationship with Reproductive Behavior
English
Deviche, P. [> > > >]
Delville, Y. [> > > >]
Balthazart, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
22-Sep-1987
Brain Research
421
1-2
105-16
Yes (verified by ORBi)
International
0006-8993
[en] An in vitro radioenzymatic assay and purification procedure by thin-layer chromatography were used to study the metabolism of dihydrotestosterone (DHT) into 3 alpha- and 3 beta-androstanediols by the brain and cloacal gland of Japanese quail. Kinetic studies showed that these 2 metabolites are produced in a linear fashion with respect to time of incubation for up to 15 min but that they continue to accumulate for up to 4 h. The maximum velocity of these reactions is high (nmol/mg protein/15 min), but the affinities of the enzymes for DHT are low (in the microM range). The enzymatic activities are not evenly distributed in the brain: they are high in the tuberal hypothalamus and lobus parolfactorius but low in the preoptic area and anterior hypothalamus. Enzyme activities are not markedly affected by treatment of the birds with either testosterone or DHT. The activity of these enzymes is lower in the preoptic area and tuberal hypothalamus of DHT-treated birds which display female-directed sexual behavior than in the same brain areas of birds which are sexually inactive. We discuss the relationships between this reductive metabolism of DHT and the activational effects of the steroid on sexual behavior.
http://hdl.handle.net/2268/28494

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