Article (Scientific journals)
Central and Peripheral Metabolism of 5 Alpha-Dihydrotestosterone in the Male Japanese Quail: Biochemical Characterization and Relationship with Reproductive Behavior
Deviche, P.; Delville, Y.; Balthazart, Jacques
1987In Brain Research, 421 (1-2), p. 105-16
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Abstract :
[en] An in vitro radioenzymatic assay and purification procedure by thin-layer chromatography were used to study the metabolism of dihydrotestosterone (DHT) into 3 alpha- and 3 beta-androstanediols by the brain and cloacal gland of Japanese quail. Kinetic studies showed that these 2 metabolites are produced in a linear fashion with respect to time of incubation for up to 15 min but that they continue to accumulate for up to 4 h. The maximum velocity of these reactions is high (nmol/mg protein/15 min), but the affinities of the enzymes for DHT are low (in the microM range). The enzymatic activities are not evenly distributed in the brain: they are high in the tuberal hypothalamus and lobus parolfactorius but low in the preoptic area and anterior hypothalamus. Enzyme activities are not markedly affected by treatment of the birds with either testosterone or DHT. The activity of these enzymes is lower in the preoptic area and tuberal hypothalamus of DHT-treated birds which display female-directed sexual behavior than in the same brain areas of birds which are sexually inactive. We discuss the relationships between this reductive metabolism of DHT and the activational effects of the steroid on sexual behavior.
Disciplines :
Zoology
Neurosciences & behavior
Endocrinology, metabolism & nutrition
Author, co-author :
Deviche, P.
Delville, Y.
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Language :
English
Title :
Central and Peripheral Metabolism of 5 Alpha-Dihydrotestosterone in the Male Japanese Quail: Biochemical Characterization and Relationship with Reproductive Behavior
Publication date :
22 September 1987
Journal title :
Brain Research
ISSN :
0006-8993
eISSN :
1872-6240
Publisher :
Elsevier, Netherlands
Volume :
421
Issue :
1-2
Pages :
105-16
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 November 2009

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