Article (Scientific journals)
Immunocytochemical Localization of Aromatase in the Brain
Balthazart, Jacques; Foidart, Agnès; Harada, N.
1990In Brain Research, 514 (2), p. 327-33
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Abstract :
[en] An immunocytochemical peroxidase-antiperoxidase procedure using a purified polyclonal antibody raised against human placental aromatase was used to localize aromatase-containing cells in the Japanese quail brain. Immunoreactive cells were found only in the preoptic area and hypothalamus, with a high density of positive cells being present in the sexually dimorphic medial preoptic nucleus, in the ventromedial nucleus of the hypothalamus and in the infundibulum. The positive material was localized in the perikarya and in adjacent cytoplasmic processes. Aromatase-containing cells were a specific marker for the sexually dimorphic preoptic nucleus. Treatment with testosterone produced a 6-fold increase in the aromatase activity of the preoptic area and a 4-fold increase in the number of immunoreactive cells in the medial preoptic nucleus. Thus, the increase in aromatase activity observed after testosterone administration is caused by a change in enzyme concentration.
Disciplines :
Zoology
Endocrinology, metabolism & nutrition
Neurosciences & behavior
Author, co-author :
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Foidart, Agnès ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Harada, N.
Language :
English
Title :
Immunocytochemical Localization of Aromatase in the Brain
Publication date :
30 April 1990
Journal title :
Brain Research
ISSN :
0006-8993
eISSN :
1872-6240
Publisher :
Elsevier, Netherlands
Volume :
514
Issue :
2
Pages :
327-33
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 November 2009

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