Antimalarial compounds isolated from plants used in traditional medicine.

[en] OBJECTIVES: This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given for substances with IC50 values < or = 11 microm. KEY FINDINGS: Malaria is a major parasitic disease in many tropical and subtropical regions and is responsible for more than 1 million deaths each year in Africa. The rapid spread of resistance encourages the search for new active compounds. Nature and particularly plants used in traditional medicine are a potential source of new antimalarial drugs as they contain molecules with a great variety of structures and pharmacological activities. SUMMARY: A large number of antimalarial compounds with a wide variety of structures have been isolated from plants and can play a role in the development of new antimalarial drugs. Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Bero, Joanne

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Quetin-Leclercq, Joelle

Language :

English

Title :

Antimalarial compounds isolated from plants used in traditional medicine.

Publication date :

2009

Journal title :

Journal of Pharmacy and Pharmacology

ISSN :

0022-3573

eISSN :

2042-7158

Publisher :

Pharmaceutical Press, London, United Kingdom

Volume :

Issue :

Pages :

1401-33

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 November 2009

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127

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109

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