Article (Scientific journals)
Traitement hormonal apres cancer du sein. Oui ... ou non?
Foidart, Jean-Michel; Desreux, Joëlle; Lifrange, Eric et al.
2003In Revue Médicale de Liège, 58 (2), p. 77-82
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Keywords :
Estrogens; Estrogens and Progestins; Tibolone; Hormone replacement therapy; Breast cancer
Abstract :
[en] Clinical and experimental studies indicate that combined unique conjugated estrogens and medroxyprogesterone acetate moderately increase the risk of breast cancer in postmenopausal women. Classically, hormone replacement therapy is contra-indicated in women with a past history of breast cancer due to the fear of recurrence. However, these postmenopausal patients complain about hot flushes and adjuvant hormonal therapies (such as aromatase inhibitors, SERMs and Tamoxifen...) aggravate their symptoms. Observational studies and their meta-analyses do not show a deleterious effect but rather a beneficial impact of hormone replacement therapy among women with a past history of breast cancer. We summarise all these studies and their biological, clinical and epidemiological interpretations. We conclude that short term hormone replacement therapy is safe among those women requesting a replacement therapy after complete information. It is however advisable to conclude definitely only when prospective randomised trials with estradiol or tibolone (a promising alternative) will be available. Such ongoing studies will allow to conclude definitely the possible benefits and risks of hormone replacement therapy among patients with a past history of breast cancer.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Desreux, Joëlle ;  Centre Hospitalier Universitaire de Liège - CHU > Sénologie
Lifrange, Eric ;  Centre Hospitalier Universitaire de Liège - CHU > Sénologie
Colin, Claude ;  Université de Liège - ULiège > Gynécologie - Obstétrique
Language :
French
Title :
Traitement hormonal apres cancer du sein. Oui ... ou non?
Alternative titles :
[en] Hormone Replacement Therapy after Breast Cancer. Yes...Or No?
Publication date :
February 2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
58
Issue :
2
Pages :
77-82
Peer reviewed :
Peer reviewed
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since 21 March 2010

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