Differential Effects of D1 and D2 Dopamine-Receptor Agonists and Antagonists on Appetitive and Consummatory Aspects of Male Sexual Behavior in Japanese Quail
Balthazart, Jacques; Castagna, C.; Ball, G. F.
1997 • In Physiology and Behavior, 62 (3), p. 571-80
[en] Pharmacological studies in Japanese quail based on behavioral tests with a variety of dopaminergic compounds suggest that the activation of D2 dopamine receptors inhibits, and the activation of D1 dopamine receptors enhances, appetitive and consummatory components of male sexual behavior. This hypothesis was tested by studying the behavioral effects of specific D1 and D2 dopaminergic-receptor agonists and antagonists in castrated male Japanese quail chronically treated with exogenous testosterone (subcutaneous Silastic implants). The effects of 5 compounds were tested: 1 D1 (SKF38393) and 2 D2 (PPHT and quinpirole) agonists, and 1 D1 (SCH23390) and 1 D2 (Spiperone) antagonist. All compounds were tested at a low and a high dose (0.1 and 1 mg/kg, respectively, for all drugs, except spiperone where the doses were 2 and 10 mg/kg). A consistent effect of all drugs on consummatory sexual behavior was observed: it was stimulated by the D1 agonist and the D2 antagonist, but inhibited by the D1 antagonist and the D2 agonists. Far fewer effects of the treatments were detected on the measures of appetitive behavior. Measures of appetitive behavior were decreased by the 2 D2 agonists, but not affected by the other treatments. These data suggest that male copulatory behavior in quail is stimulated by dopamine acting on D1 receptors, but inhibited by activation of the D2 receptor subtype. The partial dissociation observed between the effects of the same treatments on appetitive and consummatory aspects of sexual behavior also suggests that these 2 behavioral systems may be controlled by the action of dopamine on different neuronal systems.
Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Castagna, C.
Ball, G. F.
Language :
English
Title :
Differential Effects of D1 and D2 Dopamine-Receptor Agonists and Antagonists on Appetitive and Consummatory Aspects of Male Sexual Behavior in Japanese Quail
Absil P., Das S., Balthazart J. Effects of apomorphine on sexual behavior in male quail. Pharmacol. Biochem. Behav. 47:1994;77-88.
Absil P., Foidart A., Houbart M., Balthazart J. Quantitative analysis of dopaminergic inputs to aromatase-containing areas in the quail brain. Soc. Neurosci. Abstr. 21:1995;101.
Absil P., Foidart A., Surlemont C., Balthazart J. Dopaminergic inputs to aromatase-containing areas in the quail brain identified by double label immunocytochemistry and retrograde tracing. Soc. Neurosci. Abstr. 20:1994;827.
Adkins E. K., Adler N. T. Hormonal control of behavior in the Japanese quail. J. Comp. Physiol. Psychol. 81:1972;27-36.
Bailhache T., Balthazart J. The catecholaminergic system of the quail brain: Immunocytochemical studies of dopamine β -hydroxylase and tyrosine hydroxylase. J. Comp. Neurol. 329:1993;230-256.
Bailhache T., Foidart A., Surlemont C., Harada N., Balthazart J. Catecholaminergic innervation of aromatase and estrogen receptor-immunoreactive cells in the quail brain. Soc. Neurosci. Abstr. 17:1991;269.
Balthazart J., Absil P. Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by retrograde tracing combined with tyrosine hydroxylase immunocytochemistry. J. Comp. Neurol. 382:1997;401-428.
Balthazart J., Ball G. F. Is dopamine interacting with aromatase to control sexual behavior in male quail? Poultry Sci. Rev. 4:1992;217-233.
Balthazart, J.; Ball, G. F. Neuroendocrine regulation of appetitive and consummatory aspects of male sexual behavior in Japanese quail. In: Etches, R.; Harvey, S., eds. Perspectives in avian endocrinology. Bristol, UK: Society for Endocrinology (in press).
Balthazart J., Castagna C., Ball G. F. Aromatization inhibition blocks the activation and sexual differentiation of appetitive male sexual behavior in Japanese quail. Behav. Neurosci. 111:1997;381-387.
Balthazart J., Foidart A., Absil P., Harada N. Effects of testosterone and its metabolites on aromatase-immunoreactive cells in the quail brain: Relationship with the activation of male reproductive behavior. J. Steroid Biochem. Mol. Biol. 56:1996;185-200.
Balthazart J., Reid J., Absil P., Foidart A., Ball G. F. Appetitive as well as consummatory aspects of male sexual behavior in quail are activated by androgens and estrogens. Behav. Neurosci. 109:1995;485-501.
Balthazart J., Schumacher M. Estradiol contributes to the postnatal demasculinization of female Japanese quail (Coturnix coturnix japonica). Horm. Behav. 18:1984;287-297.
Bitran D., Hull E. M. Pharmacological analysis of male rat sexual behavior. Neurosci. Biobehav. Rev. 11:1987;365-389.
Blackburn J. R., Pfaus J. G., Phillips A. G. Dopamine functions in appetitive and defensive behaviours. Prog. Neurobiol. 39:1992;247-279.
Castagna C., Absil P., Balthazart J. Central effects of vasotocin on appetitive and consummatory sexual behavior in male quail. Soc. Neurosci. Abstr. 22:1996;2068.
Castagna, C.; Absil, P.; Foidart, A.; Balthazart, J. Systemic and intracerebroventricular injections of vasotocin inhibit appetitive and consummatory components of male sexual behavior in Japanese quail. Behav. Neurosci. (in press).
Castagna, C.; Ball, G. F.; Balthazart, J. Effects of dopamine agonists on appetitive and consummatory male sexual behavior in Japanese quail. Pharmacol. Biochem. Behav. (in press).
Clark J.T., Smith E. R. Effects of apomorphine on sexual behavior in young and middle-aged rats. Neurobiol. Aging. 8:1987;153-157.
Cooper J. R., Bloom F. E., Roth R. H. The biochemical basis of neuropharmacology. 1996;Oxford University Press, New York.
Crawford L. L., Holloway K. S., Domjan M. The nature of sexualreinforcement. J. Exp. Anal. Behav. 60:1993;55-66.
Domjan M., Hall S. Determinants of social proximity in Japanese quail (Coturnix coturnix japonica): male behavior. J. Comp. Psychol. 100:1986;59-67.
Domjan M., Hall S. Sexual dimorphism in the social proximity behavior of Japanese quail (Coturnix coturnix japonica). J. Comp. Psychol. 100:1986;68-71.
Domjan M. J. Formulation of a behavior system for sexual conditioning. Psychonomics Bull. Rev. 1:1994;421-428.
Everitt B. J. Sexual motivation:a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses in male rats. Neurosci. Biobehav. Rev. 14:1990;217-232.
Everitt B. J. Neuroendocrine mechanisms underlying appetitive and consummatory elements of masculine sexual behavior. Bancroft J. The pharmacology of sexual function and dysfunction. 1995;15-32 Elsevier, Amsterdam.
Gingrich J. A., Caron M. G. Recent advances in the molecular biology of dopamine receptors. Ann. Rev. Neurosci. 16:1993;299-321.
Hull E. M. Dopaminergic influences on male rat sexual behavior. Micevych P. E., Hammer R. P. Jr. Neurobiological effects of sex steroid hormones. 1995;234-253 Cambridge University Press, Cambridge.
Hull E. M., Bazzett T. J., Warner R. K., Eaton R. C., Thompson J. T. Dopamine receptors in the ventral tegmental area modulate male sexual behavior in rats. Brain Res. 512:1990;1-6.
Hull E. M., Bitran D., Pehek E. A., Warner R. K., Band L. C., Homes G. M. Dopaminergic control of male sex behavior in rats: effects of an intracerebrally infused agonist. Brain Res. 370:1986;73-81.
Hutchison R. E. Hormonal differentiation of sexual behavior in Japanese quail. Horm. Behav. 11:1978;363-387.
Kandel E. R. Disorders of thought: schizophrenia. Kandel E. R., Schwartz J. H., Jessell T. M. Principles of neural science. 3rd ed. 1991;853-868 Elsevier, New York.
Martin P., Bateson P. Measuring behaviour. An introductory guide. 1986;Cambridge University Press, Cambridge.
Mas M., Fumero B., Perez-Rodriguez I. Induction of mating behavior by apomorphine in sexually sated rats. Eur. J. Pharmacol. 280:1995;331-334.
Meisel R. L., Sachs B. D. The physiology of male sexual behavior. Knobil E., Neill J. D. The physiology of reproduction. 2:1994;3-105 Raven Press, New York.
Panzica G. C., Viglietti-Panzica C., Balthazart J. The sexually dimorphic medial preoptic nucleus of quail: a key brain area mediating steroid action on male sexual behavior. Front. Neuroendocrinol. 17:1996;51-125.
Pehek E. A., Thompson J. T., Hull E. M. The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat. Brain Res. 500:1989;325-332.
Pfaus J. G., Frank A. Beach Award - Homologies of animal and human sexual behaviors. Horm. Behav. 30:1996;187-200.
Pfaus J. G., Phillips A. G. Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav. Neurosci. 105:1991;727-743.
Pomerantz S. M. Dopaminergic influences on male sexual behavior of rhesus monkeys: Effects of dopamine agonists. Pharmacol. Biochem. Behav. 41:1992;511-517.
Richfield E. R., Young A. B., Penney J. B. Comparative distribution of dopamine D-1 and D-2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys. J. Comp. Neurol. 262:1987;446-463.
Sachs B. D. Photoperiodic control of the cloacal gland of the Japanese quail. Science. 157:1967;201-203.
Sachs B. D., Akasofu K., McEldowney S. S. Effects of copulation on apomorphine-induced erection in rats. Pharmacol. Biochem. Behav. 48:1994;423-428.
Schumacher M., Balthazart J. The postnatal demasculinization of sexual behavior in the Japanese quail. Horm. Behav. 18:1984;298-312.
Smeets W. J. A. J., Reiner A. Phylogeny and development of catecholamine systems in the CNS of vertebrates. 1994;Cambridge University Press, Cambridge.
Van Furth W. R., Wolterink G., Van Ree J. M. Regulation of masculine sexual behavior: Involvement of brain opioids and dopamine. Brain Res. Rev. 21:1995;162-184.
