The role of cellular and prodrug-associated factors in the bystander effect induced by the Varicella zoster and the Herpes simplex virus thymidine kinases in suicide gene therapy
Grignet, Christine ; Université de Liège - ULiège > Services administratifs généraux > Protection et hygiène du travail (SUPHT)
Cool, V.
Baudson, N.
Velu, Thierry
Calberg-Bacq, Claire-Michelle
Language :
English
Title :
The role of cellular and prodrug-associated factors in the bystander effect induced by the Varicella zoster and the Herpes simplex virus thymidine kinases in suicide gene therapy
Moolten F.L. (1986) Tumor chemosensitivity conferred by inserted Herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res 46:5276-5281.
Culver K.W., Ram Z., Walbridge S. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256:1550-1552.
Ram Z., Culver K.W., Walbridge S. (1993) In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53:83-88.
Vile R.G., Nelson J.A., Castleden S. (1994) Systemic gene therapy of murine melanoma using tissue-specific expression of the HSVtk gene involves an immune component. Cancer Res 54:6228-6234.
Ram Z., Culver K.W., Oshiro E.M. (1997) Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 3:1354-1361.
Sterman D.H., Treat J., Litzky L.A. (1998) Adenovirus-mediated Herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther 9:1083-1092.
Palu G., Cavaggioni A., Calvi P. (1999) Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans. Gene Ther 6:330-337.
Barba D., Hardin J., Ray J. (1993) Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 79:729-735.
Freeman S.M., Abboud C.N., Whartenby K.A. (1993) The bystander effect: Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53:5274-5283.
Colombo B.M., Benedetti S., Ottolenghi S. (1995) The bystander effect: Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther 6:763-772.
Samejima Y., Meruelo D. (1995) Bystander killing induces apoptosis and is inhibited by forskolin. Gene Ther 2:50-58.
Hamel W., Magnelli L., Chiarugi V.P. (1996) Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 56:2697-2702.
Bi W.L., Parysek L.M., Warnick R. (1993) In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther 4:725-731.
Fick J., Barker II F.G., Dazin P. (1995) The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA 92:11071-11075.
Elshami A.A., Saavedra A., Zhang H. (1996) Gap junctions play a role in the bystander effect of the Herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Ther 3:85-92.
Mesnil M., Piccoli C., Tiraby G. (1996) Bystander killing of cancer cells by Herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci USA 93:1831-1835.
Ishii-Morita H., Agbaria R., Mullen C.A. (1997) Mechanism of bystander effect killing in the Herpes simplex thymidine kinase gene therapy model of cancer treatment. Gene Ther 4:244-251.
Vrionis F.D., Wu J.K., Qi P. (1997) The bystander effect exerted by tumor cells expressing the Herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions. Gene Ther 4:577-585.
Yang L., Chiang Y., Lenz H.-J. (1998) Intercellular communication mediates the bystander effect during Herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum Gene Ther 9:719-728.
Caruso M., Panis Y., Gagandeep S. (1993) Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 90:7024-7028.
Tapscott S.J., Miller A.D., Olson J.M. (1994) Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. Proc Natl Acad Sci USA 91:8185-8189.
Gagandeep S., Brew R., Green B. (1996) Prodrug-activated gene therapy: Involvement of an immunological component in the bystander effect. Cancer Gene Ther 3:83-88.
Freeman S.M., Ramesh R., Marrogi A.J. (1997) Immune system in suicide gene therapy. Lancet 349:2-3.
Kianmanesh A.R., Perrin H., Panis Y. (1997) A distant bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Ther 8:1807-1814.
Ramesh R., Marrogi A.J., Munshi A. (1996) In vivo analysis of the bystander effect: A cytokine cascade. Exp Hematol 24:829-838.
Mullen C.A., Anderson L., Woods K. (1998) Ganciclovir chemoablation of Herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses. Hum Gene Ther 9:2019-2030.
Barba D., Hardin J., Sadelain M. (1994) Development of antitumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 91:4348-4352.
Roberts G.B., Fyfe J.A., McKee S.A. (1993) Varicella zoster virus thymidine kinase. Characterization and substrate specificity. Biochem Pharmacol 46:2209-2218.
Grignet-Debrus C., Calberg-Bacq C.-M. (1997) Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Gene Ther 4:560-569.
Grignet-Debrus C., Cool V., Baudson N. (2000) Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU) against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase. Cancer Gene Ther 7:215-223.
Markowitz D., Golf S., Bank A. (1988) Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400-406.
Miller A.D., Buttimore C. (1986) Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 6:2895-2902.
Labarca C., Paigen K. (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352.
Cool V., Pirotte B., Gerard C. Curative potential of Herpes simplex virus thymidine kinase gene transfer in rats with 9L..
Cirenei N., Colombo B.M., Mesnil M. (1998) In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: Consequences for HSVtk/GCV anticancer gene therapy. Gene Ther 5:1221-1226.
Danos O. (1991) Construction of retroviral packaging cell lines., Collins MKL, ed. Practical Molecular Virology; Methods in Molecular Biology. Vol.8. NJ: Humana Press; 17-27.
Coligan J.E., Kruisbeek A.M., Margulies D.H. (1991) Examples of apoptosis in the immune system. Current Protocols in Immunology , New York: Greene Publishing Associates and Wiley-Interscience Publishers; 1:31712.
El-Fouly M.H., Trosko J.E., Chang C.-C. (1987) Scrape loading and dye transfer. Exp Cell Res 168:422-430.
Chaumontet C., Bex V., Galliard-Sanchez I. (1994) Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells. Carcinogenesis 15:2325-2330.
Goldberg G.S., Bechberger J.F., Naus C.C.G. (1995) A preloading method of evaluating gap junctional communication by fluorescent dye transfer. Biotechniques 18:490-497.
Melcher A., Todryk S., Hardwick N. (1998) Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat Med 4:581-587.
Naus C.C.G., Belliveau D.J., Bechberger J.F. (1990) Regional differences in connexin 32 and connexin 43 messenger RNAs in rat brain. Neurosci Lett 111:297-302.
Musil L.S., Cunningham B.A., Edelman G.M. (1990) Differential phosphorylation of the gap junction protein connexin 43 junctional communication-competent and -deficient cell lines. J Cell Biol 111:2077-2088.
Eghbali B., Kessler J.A., Reid L.M. (1991) Involvement of gap junctions in tumorigenesis: Transfection of tumor cells with connexin 32 cDNA retards growth in vivo. Proc Natl Acad Sci USA 88:10701-10705.
Mesnil M., Krutovskikh V., Piccoli C. (1995) Negative growth control of HeLa cells by connexin genes: Connexin species specificity. Cancer Res 55:629-639.
Dilber M.S., Abedi M.R., Christensson B. (1997) Gap junctions promote the bystander effect of Herpes simplex virus thymidine kinase in vivo. Cancer Res 57:1523-1528.
Davidson J.S., Baumgarten I.M., Harley E.H. (1986) Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochem Biophys Res Commun 134:29-36.
Kaneko Y., Tsukamoto A. (1995) Gene therapy of hepatoma: Bystander effects and nonapoptotic cell death induced by thymidine kinase and ganciclovir. Cancer Lett 96:105-110.
Denning C., Pitts J.D. (1997) Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes. Hum Gene Ther 8:1825-1835.
Boucher P.D., Ruch R.J., Shewach D.S. (1998) Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing Herpes simplex virus thymidine kinase. Hum Gene Ther 9:801-804.
Lee S.W., Tomasetto C., Paul D. (1992) Transcriptional down-regulation of gap junctional proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol 118:1213-1221.
Tomasetto C., Neveu M.J., Daley J. (1993) Specificity of gap junction communication among human mammary cells and connexin transfectants in culture. J Cell Biol 122:157-167.
Monaghan P., Clarke C., Perusinghe N.P. (1996) Gap junction distribution and connexin expression in human breast. Exp Cell Res 223:29-38.
Hirschi K.K., Xu C.-E., Tsukamoto T. (1996) Gap junction genes, Cx26 and Cx43, individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ 7:861-870.
Li H., Liu T.-F., Lazrak A. (1996) Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 134:1019-1030.
Park J.Y., Elshami A.A., Amin K. (1997) Retinoids augment the bystander effect in vitro and in vivo in Herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy. Gene Ther 4:909-917.
Carystinos G.D., Katabi M.M., Laird D.W. (1999) Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy. Clin Cancer Res 5:61-68.
Touraine R.L., Vahanian N., Ramsey W.J. (1998) Enhancement of the Herpes simplex virus thymidine kinase/ganciclovir by-stander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum Gene Ther 9:2385-2391.
Mesnil M., Piccoli C., Yamasaki H. (1997) A tumor-suppressor gene, Cx26, also mediates the bystander effect in HeLa cells. Cancer Res 57:2929-2932.
Degreve B., De Clercq E., Balzarini J. (1999) Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine analogues. Gene Ther 6:162-170.
Veenstra R.D., Wang H.Z., Beblo D.A. (1995) Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res 77:1156-1165.
Bevans C.G., Kordel M., Rhee S.K. (1998) Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J Biol Chem 273:2808-2816.
Rubsam L.Z., Boucher P.D., Murphy P.J. (1999) Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with Herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res 59:669-675.
Ghoumari A.M., Mouawad R., Zerrouqi A. (1998) Actions of HSVtk and connexin 43 gene delivery on gap junctional communication and drug sensitization in hepatocellular carcinoma. Gene Ther 5:1114-1121.
Bai S., Du L., Liu W. (1999) Tentative novel mechanism of the bystander effect in glioma gene therapy with HSV-TK/GCV system. Biochem Biophys Res Commun 259:455-459.
Princen F., Robe P., Lechanteur C. (1999) A cell type- specific and gap junction-independent mechanism for the Herpes simplex virus- 1 thymidine kinase gene/ganciclovir-mediated bystander effect. Clin Cancer Res 5:3639-3644.
Trinh Q.T., Austin E.A., Murray D.M. (1995) Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res 55:4808-4812.
Hall S.J., Sanford M.A., Atkinson G. (1998) Induction of potent antitumor natural killer cell activity by Herpes simplex virus thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer. Cancer Res. 58:3221-3225.
