Article (Scientific journals)
Growth hormone response to apomorphine in panic disorder: comparison with major depression and normal controls.
Pichot, William; Hansenne, Michel; Gonzalez Moreno, Antonio et al.
1995In European Archives of Psychiatry and Clinical Neuroscience, 245 (6), p. 306-308
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Keywords :
Adult; Apomorphine/diagnostic use/pharmacology; Depressive Disorder/blood/diagnosis/psychology; Dopamine/metabolism; Dopamine Agonists/diagnostic use/pharmacology; Growth Hormone/blood/metabolism; Humans; Hypothalamo-Hypophyseal System/drug effects; Male; Middle Aged; Panic Disorder/blood/psychology; Pituitary-Adrenal System/drug effects; Psychiatric Status Rating Scales; Radioimmunoassay
Abstract :
[en] Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 male drug-free inpatients meeting Research Diagnostic Criteria for panic disorder who were compared with 10 male major depressive inpatients and 10 male normal controls. The three groups differed significantly in the GH peak response (mean +/- SD): 27.8 +/- 12.5 ng/ml in panics, 5.4 +/- 4.0 ng/ml in major depressives, and 25.8 +/- 11.3 ng/ml in normal controls (F(2,27) = 15.3; P = 0.00003). Although there were significant differences between panics and major depressives (P = 0.00004), and between major depressives and controls (P = 0.00004), panics did not significantly differ from controls. These results do not support the hypothesis of an overlap between panic and affective disorders, and suggest that the hypothalamo-GH-somatomedin axis could be intact in panic disorder.
Disciplines :
Psychiatry
Author, co-author :
Pichot, William;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Hansenne, Michel  ;  Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Gonzalez Moreno, Antonio;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Ansseau, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Growth hormone response to apomorphine in panic disorder: comparison with major depression and normal controls.
Publication date :
1995
Journal title :
European Archives of Psychiatry and Clinical Neuroscience
ISSN :
0940-1334
eISSN :
1433-8491
Publisher :
Springer Verlag, Berlin, Germany
Volume :
245
Issue :
6
Pages :
306-308
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 November 2009

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