Reference : Relationship between alpha 2-adrenergic function and suicidal behavior in depressed p...
Scientific journals : Article
Human health sciences : Psychiatry
http://hdl.handle.net/2268/28121
Relationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
English
Pitchot, William mailto [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Ansseau, Marc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Gonzalez Moreno, A. [> > > >]
Wauthy, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Psychiatrie et psychologie médicale >]
Hansenne, Michel mailto [Université de Liège - ULg > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles >]
von Frenckell, R. [> > > >]
1994
Psychiatry Research
Elsevier North Holland Biomedical Press
52
2
115-23
Yes (verified by ORBi)
0165-1781
Limerick
Ireland
[en] Adult ; Clonidine/diagnostic use/pharmacology ; Depressive Disorder/diagnosis/psychology ; Female ; Growth Hormone/metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/cerebrospinal fluid ; Norepinephrine/metabolism ; Psychiatric Status Rating Scales ; Radioimmunoassay ; Receptors, Adrenergic, alpha-2/metabolism ; Suicide, Attempted
[en] The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior.
http://hdl.handle.net/2268/28121

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