Article (Scientific journals)
Suicidal behavior and growth hormone response to apomorphine test.
Pitchot, William; Hansenne, Michel; Gonzalez Moreno, Antonio et al.
1992In Biological Psychiatry, 31 (12), p. 1213-1219
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Keywords :
Adult; Apomorphine/diagnostic use; Depressive Disorder/blood/diagnosis/psychology; Female; Growth Hormone/blood; Humans; Male; Receptors, Dopamine/drug effects/physiology; Suicide/psychology; Suicide, Attempted/psychology; Violence
Abstract :
[en] Several cerebrospinal fluid (CSF) studies have provided support for a possible role for the dopaminergic system as a biological correlate of suicidal behavior. Indeed, low CSF levels of the dopamine metabolite homovanillic acid (HVA) have been described in depressed patients with a history of suicide attempts. In this study, we assessed the dopamine receptor sensitivity in relationship to suicidal behavior by measuring growth hormone (GH) response to apomorphine 0.5 mg subcutaneously (sc) in 15 DSM-III-R (APA 1987) major depressive inpatients with a history of suicide attempts, compared to age-matched and gender-matched major depressive inpatients without a history of suicide. Patients with a history of suicidal behavior exhibited a significantly lower GH response to apomorphine than patients who never attempted suicide (t = 3.60, df = 1.28, p = 0.0012). Therefore, these results suggest that a blunted GH response to apomorphine could represent a biological marker of suicidal behavior.
Disciplines :
Psychiatry
Author, co-author :
Pitchot, William ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Hansenne, Michel  ;  Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Gonzalez Moreno, Antonio;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Ansseau, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Suicidal behavior and growth hormone response to apomorphine test.
Publication date :
1992
Journal title :
Biological Psychiatry
ISSN :
0006-3223
Publisher :
Elsevier, New York, United States - New York
Volume :
31
Issue :
12
Pages :
1213-1219
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 November 2009

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