Reference : THE FUNCTION OF HMG-BOX TRANSCRIPTION FACTORS Sox4a AND Sox4b IN ZEBRAFISH BONE DEVELOPM...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/27743
THE FUNCTION OF HMG-BOX TRANSCRIPTION FACTORS Sox4a AND Sox4b IN ZEBRAFISH BONE DEVELOPMENT AND HOMEOSTASIS.
English
Aceto, Jessica mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Motte, Patrick mailto [Université de Liège - ULg > Département des sciences de la vie > Génomique fonctionnelle et imagerie moléculaire végétale >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Muller, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
2008
Journal of Gravitational Physiology : A Journal of the International Society for Gravitational Physiology
15
115
Yes (verified by ORBi)
International
1077-9248
[en] Sox4a ; Sox4b ; HOMEOSTASIS
[en] In mammals, the Sox4 gene is involved in development of endocardial crests, the brain, the lung, teeth, gonads and lymphocytes. Recently, Sox4 was shown to control bone mass and mineralization in mice. In zebrafish, two homologs for the mammalian Sox4 are present, sox4a and sox4b. Here we investigate the function of the sox4a and sox4b genes in cartilage and bone development in zebrafish. Therefore, we focus our attention on the first bone structures to be formed, the head skeleton and more precisely the pharyngeal cartilage. We show that both genes are expressed in the pharyngeal region, albeit at different time points during development. Double in situ hybridization experiments are used to exactly define the particular tissues where they are expressed. Furthermore, microinjection experiments of antisense oligonucleotides are used to block translation of these specific genes and to define their precise function during cartilage and bone development.
Giga-Development and Stem Cells
http://hdl.handle.net/2268/27743

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