Reference : Novel Stealthy Gd(III)-DOTA/polymer Conjugates for Magnetic Resonance Imaging (MRI)
Scientific congresses and symposiums : Unpublished conference
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/27714
Novel Stealthy Gd(III)-DOTA/polymer Conjugates for Magnetic Resonance Imaging (MRI)
English
Grogna, Mathurin [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Bémelmans, Stéphanie [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Vanasschen, Christian [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
Desreux, Jean-François mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
Luxen, André mailto [University of Liège (ULg) > Department of Chemistry > Cyclotron Research Center > >]
Cloots, Rudi mailto [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry) > Center for Education and Research on Macromolecules (CERM) > >]
14-May-2009
1
No
No
National
Belgian Polymer Group (BPG) annual meeting 2009
14/05/2009 - 15/05/2009
Jérôme Christine, ULg
Duwez Anne-Sophie, ULg
Bontinck Dirk, Cytec
Houffalize
Belgium
[en] magnetic resonance imaging (MRI)
[en] Magnetic resonance imaging (MRI) is a routine diagnostic tool in modern clinical medicine. MRI has many advantages as a diagnostic imaging modality. It is noninvasive, delivers no radiation, and has excellent (submillimeter) spatial resolution. Some Gadolinium(III) complexes are commonly used to enhance the contrast between adjacent tissues when the resolution/sensitivity of MRI is too low. Because free Gd3+ is very toxic in doses required for MRI, Gd(III) is chelated by poly(amino-carboxylate) such as diethylenetriamine pentaacetic acid (DTPA) or 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Although DTPA/Gd3+ and DOTA/Gd3+ are water soluble, they have a very short circulation lifetime in blood, a low molecular weight and a short rotational time that make the contrast poor. To enhance the contrast, the Gd3+/complex doses have to be increased. In order to increase the sensitivity of the technique, while not increasing the concentration of the contrast agent, we were investigating different strategies to improve (i) the circulation lifetime in blood, (ii) the relaxation rate of Gd(III) (and consequently, the contrasting efficiency) and (iii) the targeting of the contrast agent. This presentation aims at reporting how a multifunctional (co)polymer can be designed and exploited for improving the contrasting ability and bioavailability of gadolinium-based complexes.
Center for Education and Research on Macromolecules (CERM) ; Cyclotron Research Center
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/27714

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