ORBi: Adamantidis Antoine - Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice

Reference : Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/27630

Title :	Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice
Language :	English
Author, co-author :	Adamantidis, Antoine [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
	Salvert, D. [> >]
	Goutagny, R. [> >]
	Lakaye, Bernard [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
	Gervasconi, D. [> >]
	Grisar, Thierry [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
	Luppi, P. H. [> >]
	Fort, P. [> >]
Publication date :	2008
Journal title :	European Journal of Neuroscience
Publisher :	Blackwell Science
Volume :	27
Issue/season :	7
Pages :	1793-800
Audience :	International
ISSN :	0953-816X
e-ISSN :	1460-9568
City :	Paris
Country :	France
Abstract :	[en] Growing amounts of data indicate involvement of the posterior hypothalamus in the regulation of sleep, especially paradoxical sleep (PS). Accordingly, we previously showed that the melanin-concentrating hormone (MCH)-producing neurons of the rat hypothalamus are selectively activated during a PS rebound. In addition, intracerebroventricular infusion of MCH increases total sleep duration, suggesting a new role for MCH in sleep regulation. To determine whether activation of the MCH system promotes sleep, we studied spontaneous sleep and its homeostatic regulation in mice with deletion of the MCH-receptor 1 gene (MCH-R1– ⁄ – vs. MCH-R1+ ⁄ +) and their behavioural response to modafinil, a powerful antinarcoleptic drug. Here, we show that the lack of functional MCH-R1 results in a hypersomniac-like phenotype, both in basal conditions and after total sleep deprivation, compared to wild-type mice. Further, we found that modafinil was less potent at inducing wakefulness in MCH-R1– ⁄ – than in MCH-R1+ ⁄ + mice. We report for the first time that animals with genetically inactivated MCH signaling exhibit altered vigilance state architecture and sleep homeostasis. This study also suggests that the MCH system may modulate central pathways involved in the wake-promoting effect of modafinil
Permalink :	http://hdl.handle.net/2268/27630
	also: http://hdl.handle.net/2268/74913
DOI :	10.1111/j.1460-9568.2008.06129.x

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