Reference : Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/27630
Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice
English
Adamantidis, Antoine [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Salvert, D. [> >]
Goutagny, R. [> >]
Lakaye, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Gervasconi, D. [> >]
Grisar, Thierry mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Luppi, P. H. [> >]
Fort, P. [> >]
2008
European Journal of Neuroscience
Blackwell Science
27
7
1793-800
Yes (verified by ORBi)
International
0953-816X
1460-9568
Paris
France
[en] Growing amounts of data indicate involvement of the posterior hypothalamus in the regulation of sleep, especially paradoxical sleep
(PS). Accordingly, we previously showed that the melanin-concentrating hormone (MCH)-producing neurons of the rat hypothalamus
are selectively activated during a PS rebound. In addition, intracerebroventricular infusion of MCH increases total sleep duration,
suggesting a new role for MCH in sleep regulation. To determine whether activation of the MCH system promotes sleep, we studied
spontaneous sleep and its homeostatic regulation in mice with deletion of the MCH-receptor 1 gene (MCH-R1– ⁄ – vs. MCH-R1+ ⁄ +)
and their behavioural response to modafinil, a powerful antinarcoleptic drug. Here, we show that the lack of functional MCH-R1
results in a hypersomniac-like phenotype, both in basal conditions and after total sleep deprivation, compared to wild-type mice.
Further, we found that modafinil was less potent at inducing wakefulness in MCH-R1– ⁄ – than in MCH-R1+ ⁄ + mice. We report for the
first time that animals with genetically inactivated MCH signaling exhibit altered vigilance state architecture and sleep homeostasis.
This study also suggests that the MCH system may modulate central pathways involved in the wake-promoting effect of modafinil
http://hdl.handle.net/2268/27630
10.1111/j.1460-9568.2008.06129.x

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