Article (Scientific journals)
Expression of Mrna Encoding Alpha1e and Alpha1g Subunit in the Brain of a Rat Model of Absence Epilepsy
de Borman, B.; Lakaye, Bernard; Minet, Arlette et al.
1999In Neuroreport, 10 (3), p. 569-74
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Abstract :
[en] Low voltage-activated calcium channels are thought to play a key role in the generation of spike and waves discharges characteristic of absence epilepsy. Therefore, the expression level of mRNA encoding calcium channel alpha1E and alpha1G subunits was measured in the brain of genetic absence epilepsy rats from Strasbourg (GAERS). Using quantitative RT-PCR and in situ hybridization, no difference was found in alpha1G mRNA expression between GAERS and control animals, while a decreased expression of alpha1E was seen in the cerebellum and the brain stem of the GAERS. This phenomenon was not observed in young animals when the epileptic phenotype is not expressed.
Disciplines :
Neurosciences & behavior
Author, co-author :
de Borman, B.
Lakaye, Bernard ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Minet, Arlette ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Zorzi, Willy ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Vergnes, M.
Marescaux, C.
Grisar, Thierry ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Language :
English
Title :
Expression of Mrna Encoding Alpha1e and Alpha1g Subunit in the Brain of a Rat Model of Absence Epilepsy
Publication date :
10 February 1999
Journal title :
Neuroreport
ISSN :
0959-4965
eISSN :
1473-558X
Publisher :
Lippincott Williams & Wilkins, United States
Volume :
10
Issue :
3
Pages :
569-74
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 November 2009

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