Reference : Amphetamine- and cocaine-induced conditioned place preference and concomitant psychom...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/27597
Amphetamine- and cocaine-induced conditioned place preference and concomitant psychomotor sensitization in mice with genetically inactivated melanin-concentrating hormone MCH(1) receptor.
English
Tyhon, Amélie mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Lakaye, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Adamantidis, Antoine [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
2008
European Journal of Pharmacology
Elsevier Science
599
1-3
72-80
Yes (verified by ORBi)
International
0014-2999
Amsterdam
The Netherlands
[en] Amphetamine/administration & dosage/pharmacology ; Animals ; Behavior, Animal/drug effects ; Central Nervous System Stimulants/administration & dosage/pharmacology ; Cocaine/administration & dosage/pharmacology ; Conditioning, Operant/drug effects ; Dopamine Uptake Inhibitors/administration & dosage/pharmacology ; Dose-Response Relationship, Drug ; Genotype ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Psychomotor Performance/drug effects ; Receptors, Somatostatin/genetics ; Reward
[en] The melanin-concentrating hormone MCH(1) receptor has been proposed to exert an inhibitory control on monoaminergic (especially dopaminergic) activity within the mesolimbic system, which underpins drug seeking and reward. That hypothesis predicts that an inactivation of these receptors should enhance the sensitivity to drug rewarding effects. To test that prediction, we examined the propensity of mice lacking the melanin-concentrating receptor (MCH(1) KO) and their intact counterparts (WT) to form cocaine- and amphetamine-induced conditioned place preference. The conditioned rewarding effects induced by 0.375, 0.75, 1.5 and 3 mg/kg amphetamine were assessed in two sub-experiments and those induced by 1, 2, 4 and 8 mg/kg cocaine in two other sub-experiments. All mice were tested under saline for place preference 24 h following four every-other-day conditioning trials and an initial pre-conditioning session under saline. Most of the cocaine and amphetamine doses induced place preference, but without any genotype difference being revealed. Also, none of the cocaine doses induced psychomotor sensitization during conditioning, whereas amphetamine generated clear-cut dose-dependent sensitization in both genotypes. Albeit MCH(1) KO mice exhibited higher levels of psychomotor activation, the rates of sensitization were comparable across genotypes at 1.5 and 3 mg/kg amphetamine. Moreover, 0.375 and especially 0.75 mg/kg amphetamine produced a slight but yet significant sensitization in MCH(1) KO but not in their WT counterparts. Despite such an effect, the results cannot be considered as unambiguously supportive of the tested prediction.
Centre de Neurosciences Cognitives et Comportementales
http://hdl.handle.net/2268/27597
10.1016/j.ejphar.2008.09.027

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