Reference : The usefulness of operant conditioning procedures to assess long-lasting deficits fol...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/27560
The usefulness of operant conditioning procedures to assess long-lasting deficits following transient focal ischemia in mice.
English
Ferrara, André mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie de l'apprentissage et cognition animale >]
El Bejaoui, Sophie [> > > >]
Seyen, Sandrine mailto [Université de Liège - ULg > Services généraux (Faculté des sciences) > Diffusion des sciences (Réjouisciences) >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Plumier, Jean-Christophe mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale >]
2009
Behavioural Brain Research
Elsevier Science
205
2
525-34
Yes (verified by ORBi)
International
0166-4328
1872-7549
Amsterdam
Netherlands
[en] striatum ; stroke ; functional recovery
[en] In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min right middle cerebral artery occlusion (MCAO) in 129S2 mice. During 14 days after surgery, a classical sensorimotor assessment was conducted using hanging wire test, negative geotaxis test, grip strength test, accelerated rotarod test and locomotor activity-meter. In order to provide a technique for the assessment of more resistant consequences of ischemia on fine psychomotor control, the peak procedure (a modified version of the operant fixed-interval schedule of reinforcement) was used. This procedure also helped to objectify temporal perception in mice five weeks following surgery. On several sensorimotor tests, ischemic mice showed some degree of impairment which rapidly tended to improve after stroke, a profile of results substantially consistent with previous studies. Five weeks post-surgery, ischemic mice tested with the peak procedure exhibited a moderate but yet significant temporal regulation impairment along with a reduced response rate compared to control mice. The present results suggest that the peak procedure and other derived operant schedules of reinforcement may provide useful and sensitive tools for the long-term assessment of both behavioural and cognitive aspects of the consequences of an experimental ischemia.
Centre de Neurosciences Cognitives et Comportementales
http://hdl.handle.net/2268/27560
10.1016/j.bbr.2009.08.011

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