ORBi: Faucher Karine - Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin

Reference : Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells f...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Aquatic sciences & oceanology
	To cite this reference:	http://hdl.handle.net/2268/27524

Title :	Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin
Language :	English
Author, co-author :	Faucher, Karine [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Morphologie fonctionnelle et évolutive >]
	Aas-Hansen, Øyvind [ > > ]
	Damsgård, Borge [ > > ]
	Laukli, Einar [ > > ]
	Stenklev, Niels-Christian [ > > ]
Publication date :	2009
Journal title :	International Journal of Audiology
Publisher :	Taylor & Francis
Volume :	48
Issue/season :	7
Pages :	456-464
Audience :	International
ISSN :	1499-2027
e-ISSN :	1708-8186
City :	Abingdon
Country :	United Kingdom
Keywords :	[en] Fish hearing ; AEP ; SEM ; Gentamicin ; Inner ear hair cells ; Regeneration
Abstract :	[en] This study addresses the ultrastructural and functional damage and subsequent recovery of the inner ear in the Atlantic cod following intrasaccular gentamicin injection. Inner ear damage was assessed using SEM and measurements of AEP following 250-Hz pure-tone stimuli. Data from gentamicin-treated fish were compared with control (no injection) and sham (injection of saline) fish. Control fish had normal response thresholds associated with welldeveloped hair cell bundles in their macula sacculi. Sham fish had higher response thresholds compared with control fish during the first week post-intervention, but response thresholds were subsequently normal. Treated fish displayed significant inner ear damage associated with an increased average AEP threshold on the third day following treatment. Thereafter, inner ear tissue displayed signs of progressive regeneration until it was comparable to controls from the 14th day. Response thresholds were similar to those of control fish from the 17th day following treatment. These observations suggest that the macula sacculi of Atlantic cod can regenerate towards a near-complete functional and ultrastructural recovery within 17-21 days following ototoxic gentamicin treatment.
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/27524
DOI :	10.1080/14992020902738029

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Open access	PROOF.pdf		Author postprint	429.26 kB	View/Open
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