Article (Scientific journals)
Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin
Faucher, Karine; Aas-Hansen, Øyvind; Damsgård, Borge et al.
2009In International Journal of Audiology, 48 (7), p. 456-464
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Keywords :
Fish hearing; AEP; SEM; Gentamicin; Inner ear hair cells; Regeneration
Abstract :
[en] This study addresses the ultrastructural and functional damage and subsequent recovery of the inner ear in the Atlantic cod following intrasaccular gentamicin injection. Inner ear damage was assessed using SEM and measurements of AEP following 250-Hz pure-tone stimuli. Data from gentamicin-treated fish were compared with control (no injection) and sham (injection of saline) fish. Control fish had normal response thresholds associated with welldeveloped hair cell bundles in their macula sacculi. Sham fish had higher response thresholds compared with control fish during the first week post-intervention, but response thresholds were subsequently normal. Treated fish displayed significant inner ear damage associated with an increased average AEP threshold on the third day following treatment. Thereafter, inner ear tissue displayed signs of progressive regeneration until it was comparable to controls from the 14th day. Response thresholds were similar to those of control fish from the 17th day following treatment. These observations suggest that the macula sacculi of Atlantic cod can regenerate towards a near-complete functional and ultrastructural recovery within 17-21 days following ototoxic gentamicin treatment.
Disciplines :
Aquatic sciences & oceanology
Author, co-author :
Faucher, Karine ;  Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Morphologie fonctionnelle et évolutive
Aas-Hansen, Øyvind
Damsgård, Borge
Laukli, Einar
Stenklev, Niels-Christian
Language :
English
Title :
Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin
Publication date :
2009
Journal title :
International Journal of Audiology
ISSN :
1499-2027
eISSN :
1708-8186
Publisher :
Taylor & Francis, Abingdon, United Kingdom
Volume :
48
Issue :
7
Pages :
456-464
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 November 2009

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