Article (Scientific journals)
Evaluation of different bone markers in hemodialyzed patients
Cavalier, Etienne; Delanaye, Pierre; Collette, Julien et al.
2006In Clinica Chimica Acta, 371 (1-2), p. 107-111
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Keywords :
PTH; bone alkaline phosphatase; homocystein; hemodialyze; 25-OH vitamin D
Abstract :
[en] Background: Routinely, nephrologists rely on different biochemical markers like intact PTH (iPTH), bone-specific alkaline phosphatase (BALP), plasmatic calcium and phosphate. The aim of the present study was to evaluate different other bone markers like N-terminal propeptide of type I procollagen (PINP), active isoform 5b of the tartrate-resistant acid phosphatase (TRAP 5b) and beta-crossLaps (R) (CTXS) as well as full-length PTH (wPTH), presumed non-(1-84) PTH, and their ratio in the diagnosis of renal osteodystrophy with high and low turnover. We also determined 25 hydroxyvitamin D (25VTD), 1-25 dihydroxyvitamin D and homocystein (HCY). Methods: We performed those parameters on 73 patients with end-stage renal disease according to the manufacturers' instructions. Results: There were very strong correlations between the bone markers concentrations, particularly between BALP and PINP (r=0.953). We did not observe any correlation between the ratio whole PTH/non-(1-84) PTH and any of the usual bone markers. This ratio was significantly (p < 0.05) higher in low and high bone turnover patients than in normal patients according to the K/DOQI. We found a correlation between low levels of 25VTD and high levels of HCY Conclusions: BALP offers the best clinical and analytical profile as the easier marker of choice in hemodiallyzed patients for the diagnosis of bone disease. (c) 2006 Elsevier B.V All rights reserved.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Cavalier, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Delanaye, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Collette, Julien ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Evaluation of different bone markers in hemodialyzed patients
Publication date :
September 2006
Journal title :
Clinica Chimica Acta
ISSN :
0009-8981
eISSN :
1873-3492
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
371
Issue :
1-2
Pages :
107-111
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
The Authors would like to thank Clinica Chimica Acta for allowing them to present the postprint author version of the manuscript
Available on ORBi :
since 17 December 2008

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