Poster (Scientific congresses and symposiums)
The use of an adapted model allows contributing to the “Reduction” of mice used in experimental protocols: the case of the apoE–deficient (apo E-/-) mice in a model of atherosclerosis control
Cherdon, Céline; Rolin, Stéphanie; de Leval, Laurence et al.
2009Belgian Council for Animal Science Symposium
 

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Keywords :
apoE–deficient mice; apo E-/- mice; atherosclerosis; prostanoids; Thromboxane A2; PGI2; TXA2; atherosclerotic lesion; BM573; cholesterol; TP receptor; COX-1 inhibition; 3-R's; ethical rules; animal science
Abstract :
[en] Atherosclerosis is a chronic vascular disease whose development is influenced by several mediators 1. Among them, the prostanoids large family lipids generated from the metabolism of arachidonic acid by the action of COX includes various types of PGs and thromboxane. Thromboxane A2 and PGI2 are present in abnormally elevated concentration in atherosclerosis 2-3. To exert its effects TXA2 and its precursor PGH2 act at a specific receptor termed TP receptor 4. As a result, TXA2 synthase inhibitors and TP antagonists have been developed to reduce and to prevent TXA2 production and actions, respectively. The present study was undertaken in order to investigate whether BM-573, an original sulfonylurea derivate synthesized in our lab 5, and aspirin would be effective in preventing the progression of atherosclerosis in an apo E deficient mouse model.
Research center :
CREDEC et GIGA-R
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Cherdon, Céline ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Rolin, Stéphanie
de Leval, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques
Drion, Pierre ;  Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Ooms, Annie ;  Université de Liège - ULiège > Chirurgie cardio-vasculaire
Dogné, Jean-Michel
Language :
English
Title :
The use of an adapted model allows contributing to the “Reduction” of mice used in experimental protocols: the case of the apoE–deficient (apo E-/-) mice in a model of atherosclerosis control
Publication date :
01 December 2009
Event name :
Belgian Council for Animal Science Symposium
Event organizer :
BCLAS
Event place :
Blankenberge, Belgium
Event date :
1 et 2 Déc. 2009
Audience :
International
Name of the research project :
Evaluation de l’effet de modulateurs originaux du thromboxane A2 (TXA2) dans un modèle murin d’athérosclérose
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 31 October 2009

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