Reference : The use of an adapted model allows contributing to the “Reduction” of mice used in exper...
Scientific congresses and symposiums : Poster
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/27379
The use of an adapted model allows contributing to the “Reduction” of mice used in experimental protocols: the case of the apoE–deficient (apo E-/-) mice in a model of atherosclerosis control
English
Cherdon, Céline mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Rolin, Stéphanie mailto [> >]
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
Drion, Pierre mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Ooms, Annie [Université de Liège - ULg > > Chirurgie cardio-vasculaire >]
Dogné, Jean-Michel mailto [> >]
1-Dec-2009
Yes
No
International
Belgian Council for Animal Science Symposium
1 et 2 Déc. 2009
BCLAS
Blankenberge
Belgium
[en] apoE–deficient mice ; apo E-/- mice ; atherosclerosis ; prostanoids ; Thromboxane A2 ; PGI2 ; TXA2 ; atherosclerotic lesion ; BM573 ; cholesterol ; TP receptor ; COX-1 inhibition ; 3-R's ; ethical rules ; animal science
[en] Atherosclerosis is a chronic vascular disease whose development is influenced by several mediators 1. Among them, the prostanoids large family lipids generated from the metabolism of arachidonic acid by the action of COX includes various types of PGs and thromboxane. Thromboxane A2 and PGI2 are present in abnormally elevated concentration in atherosclerosis 2-3. To exert its effects TXA2 and its precursor PGH2 act at a specific receptor termed TP receptor 4. As a result, TXA2 synthase inhibitors and TP antagonists have been developed to reduce and to prevent TXA2 production and actions, respectively.
The present study was undertaken in order to investigate whether BM-573, an original sulfonylurea derivate synthesized in our lab 5, and aspirin would be effective in preventing the progression of atherosclerosis in an apo E deficient mouse model.
CREDEC et GIGA-R
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Evaluation de l’effet de modulateurs originaux du thromboxane A2 (TXA2) dans un modèle murin d’athérosclérose
Researchers ; Professionals
http://hdl.handle.net/2268/27379

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