Reference : Détermination d'un index prédictif de la preeclampsie en préconceptionnel et proposition...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/2719
Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire
French
[en] A predictive index to preeclampsia before pregnancy and a primary prevention
Emonts, Patrick mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Seaksan, Sontera [Université de Liège - ULg > CHR Citadelle >]
Seidel, Laurence mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Thoumsin, Henri [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Brichant, Jean-François mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
Albert, Adelin mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
2008
Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Masson et Cie
37
5
469-476
Yes (verified by ORBi)
International
0368-2315
Paris
France
[en] preeclampsia ; hypertension ; predictive index ; thrombophilia ; prenatal care
[en] Objective
To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention.
Material and method
Non-pregnant women with a history of PE (n =101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n =50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described.

Results
Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information.

Stategies to prevent PE in our high-risk group have given encouraging results during next pregnancy.

Conclusion
Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention.
http://hdl.handle.net/2268/2719
also: http://hdl.handle.net/2268/34081
10.1016/j.jgyn.2008.02.001

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