Article (Scientific journals)
Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire
Emonts, Patrick; Seaksan, Sontera; Seidel, Laurence et al.
2008In Journal de Gynécologie, Obstétrique et Biologie de la Reproduction, 37 (5), p. 469-476
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Keywords :
preeclampsia; hypertension; predictive index; thrombophilia; prenatal care
Abstract :
[en] Objective To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention. Material and method Non-pregnant women with a history of PE (n =101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n =50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described. Results Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information. Stategies to prevent PE in our high-risk group have given encouraging results during next pregnancy. Conclusion Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Emonts, Patrick ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Seaksan, Sontera;  Université de Liège - ULiège > CHR Citadelle
Seidel, Laurence  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Thoumsin, Henri;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Brichant, Jean-François ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Language :
French
Title :
Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire
Alternative titles :
[en] A predictive index to preeclampsia before pregnancy and a primary prevention
Publication date :
2008
Journal title :
Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
ISSN :
0368-2315
eISSN :
1773-0430
Publisher :
Masson et Cie, Paris, France
Volume :
37
Issue :
5
Pages :
469-476
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 December 2008

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