ORBi: Emonts Patrick - Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire

Reference : Détermination d'un index prédictif de la preeclampsie en préconceptionnel et proposition...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/2719

Title :	Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire
Language :	French
Alternative title :	[en] A predictive index to preeclampsia before pregnancy and a primary prevention
Author, co-author :	Emonts, Patrick [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Seaksan, Sontera [Université de Liège - ULg > CHR Citadelle >]
	Seidel, Laurence [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
	Thoumsin, Henri [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Brichant, Jean-François [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
	Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Publication date :	2008
Journal title :	Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Publisher :	Masson et Cie
Volume :	37
Issue/season :	5
Pages :	469-476
Audience :	International
ISSN :	0368-2315
City :	Paris
Country :	France
Keywords :	[en] preeclampsia ; hypertension ; predictive index ; thrombophilia ; prenatal care
Abstract :	[en] Objective To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention. Material and method Non-pregnant women with a history of PE (n =101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n =50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described. Results Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information. Stategies to prevent PE in our high-risk group have given encouraging results during next pregnancy. Conclusion Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention.
Permalink :	http://hdl.handle.net/2268/2719
	also: http://hdl.handle.net/2268/34081
DOI :	10.1016/j.jgyn.2008.02.001

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Restricted access	479.pdf	No commentary	Publisher postprint	2.35 MB	Request copy
Open access	EMONTS gynecol obstet biol reprod 2008.pdf	No commentary	Author postprint	242.59 kB	View/Open

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