Reference : Use of magnetic resonance imaging and 31p-spectroscopy to explore muscle energetics i...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Orthopedics, rehabilitation & sports medicine
Human health sciences : Rheumatology
http://hdl.handle.net/2268/27035
Use of magnetic resonance imaging and 31p-spectroscopy to explore muscle energetics in fibromyalgia patients
English
Maquet, Didier mailto [Université de Liège - ULg > Département des sciences de la motricité > Département des sciences de la motricité >]
Vanderthommen, Marc mailto [Université de Liège - ULg > Département des sciences de la motricité > Kinésithérapie spécifique et réadaptation motrice >]
Lecart, Marie-Paule mailto [Université de Liège - ULg > > Rhumatologie >]
Demoulin, Christophe mailto [Université de Liège - ULg > Département des sciences de la motricité > Kinésithérapie spécifique et réadaptation motrice >]
Leroy-Willig, A. [NMR Laboratory, Institute of Myology - Pitié-Salpêtrière, Paris, France > > > >]
Croisier, Jean-Louis mailto [Université de Liège - ULg > Département des sciences de la motricité > Kinésithérapie générale et réadaptation >]
Crielaard, Jean-Michel mailto [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques - Médecine physique et réadaptation fonctionnelle >]
Carlier, P. [NMR Laboratory, Institute of Myology - Pitié-Salpêtrière, Paris, France > > > >]
2007
Annals of the Rheumatic Diseases
BMJ Group
66
424
Yes (verified by ORBi)
International
0003-4967
1468-2060
London
United Kingdom
Eular Congress 2007
13-16 June 2007
The European League Against Rheumatism
Barcelona
Spain
[en] MAGNETIC RESONANCE IMAGING ; 31P-SPECTROSCOPY ; fibromyalgia
[en] Background: Fibromyalgia (FM) is defined as a chronic syndrome characterized by diffuse pain. FM patients generally complain of muscle fatigue during physical activities and symptoms worsening after exercise. Some studies have explored muscle performances in FM patients. Similarly, we reported that all variables of muscle performances were decreased in FM patients as compared to the controls [1]. We found that muscle impairment predominated over aerobic processes. The 31P nuclear magnetic resonance spectroscopy (NMRS) appears especially useful to study muscle energy metabolism because it is non-invasive and allows the exploration during exercise.
Objectives: The purposes were: (1) to determine the maximal transverse section (MTS) of calf muscles by Magnetic Resonance Imaging (MRI) in order to calculate the individual mechanical loads of exercise without requiring the measurement of the maximal voluntary torque; (2) to monitor, by 31P-NMRS, high-energy phosphate metabolism and intracellular pH at rest, during exercise and recovery periods by means of continuous spectra acquisitions with an adequate temporal resolution; (3) to determine an original efficacy muscular index with the help of the ergometric and spectroscopic parameters; (4) to explore the oxidative pathway by means of determination of the PCr rephosphorylation time constant.
Methods: Eight women with fibromyalgia (FM) and 30 healthy volunteers were included in this study. MRI of the dominant leg was acquired in order to determine the MTS of calf muscles and thus to calculate the different loads of exercise (dynamic plantar flexions). Subjects performed 3-6 bouts of 2 minutes with workload increments until exhaustion. Spectra were acquired continuously at rest, during the exercise and recovery periods. The analysis concerned the gamma-, alpha- and beta- ATP, Pi, PCr peaks, and intracellular pH. At the end of the exercise, the muscular efficacy index and the PCr re-phosphorylation time constant were calculated.
Results: The MTS of the ankle plantar flexors reached respectively 43 cm² and 36.7 cm² in the control and FM groups (p > 0.05). No significant difference (p > 0.05) was observed between both groups in spectroscopic data registered at rest [10.7 (control) vs 9.1 (FM) for PCr/Pi rest ; 7.01 (control) vs 6.99 (FM) for pHrest] and at the end of exercise [1.18 (control) vs 0.68 (FM) for PCr/Pi end ; 6.89 (control) vs 6.81 (FM) for pHend]. However, the muscular efficacy index was significantly reduced in FM patients (1.25) in comparison with control group (2.46) (p < 0.05). Two patients presented an index extremely low (0.3 and 0.4). The PCr time constant was not different between control subjects (27.7 s) and FM patients (25.6 s) (p > 0.05).
Conclusion: Our original protocol, not based on maximum voluntary contraction assessment, did not indicate any abnormalities in glycolytic and oxydative pathways in FM patients. We demonstrated a low efficiency of chemical to mechanical energy shift in FM patients. These results suggested a deconditioning syndrome without primitive muscular abnormalities in FM patients and displayed the importance of aerobic muscular rehabilitation.
References: [1]Maquet D, Croisier JL, Renard C, Crielaard JM. Muscle performance in patients with fibromyalgia. J Bone Spine. 2002;69:293-9.
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http://hdl.handle.net/2268/27035

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