Reference : Functional connectivity in the default network during resting state is preserved in a ve...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/27014
Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient.
English
Boly, Mélanie mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neurologie > > >]
Tshibanda, Luaba [Centre Hospitalier Universitaire de Liège - CHU > > Imagerie médicale >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Noirhomme, Quentin [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Ledoux, Didier [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Boveroux, Pierre [Centre Hospitalier Universitaire de Liège - CHU > Centre de Recherches du Cyclotron > Anesthésie et réanimation > > >]
Garweg, Christophe [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Phillips, Christophe [Université de Liège - ULg > > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
Luxen, André [Université de Liège - ULg > Centre de Recherches du cyclotron - Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron > > >]
Moonen, Gustave [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Bassetti, C. [> > > >]
Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron - Département des sciences cliniques >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Département des sciences cliniques >]
2009
Human Brain Mapping
Wiley Liss, Inc.
30
8
2393-400
Yes (verified by ORBi)
International
1065-9471
1097-0193
New York
NY
[en] functional MRI ; consciousness ; resting state ; vegetative state ; default network ; Brain/physiopathology ; Brain Death/physiopathology ; Magnetic Resonance Imaging ; Neural Pathways/physiopathology ; Persistent Vegetative State/physiopathology ; Rest/physiology ; Thalamus/physiopathology
[en] Recent studies on spontaneous fluctuations in the functional MRI blood oxygen level-dependent (BOLD) signal in awake healthy subjects showed the presence of coherent fluctuations among functionally defined neuroanatomical networks. However, the functional significance of these spontaneous BOLD fluctuations remains poorly understood. By means of 3 T functional MRI, we demonstrate absent cortico-thalamic BOLD functional connectivity (i.e. between posterior cingulate/precuneal cortex and medial thalamus), but preserved cortico-cortical connectivity within the default network in a case of vegetative state (VS) studied 2.5 years following cardio-respiratory arrest, as documented by extensive behavioral and paraclinical assessments. In the VS patient, as in age-matched controls, anticorrelations could also be observed between posterior cingulate/precuneus and a previously identified task-positive cortical network. Both correlations and anticorrelations were significantly reduced in VS as compared to controls. A similar approach in a brain dead patient did not show any such long-distance functional connectivity. We conclude that some slow coherent BOLD fluctuations previously identified in healthy awake human brain can be found in alive but unaware patients, and are thus unlikely to be uniquely due to ongoing modifications of conscious thoughts. Future studies are needed to give a full characterization of default network connectivity in the VS patients population.
http://hdl.handle.net/2268/27014
also: http://hdl.handle.net/2268/81171 ; http://hdl.handle.net/2268/33013
10.1002/hbm.20672
http://www.coma.ulg.ac.be/papers/coma_vegetative_state.html
(c) 2009 Wiley-Liss, Inc.

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