Reference : Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study.
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Neurology
http://hdl.handle.net/2268/27012
Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study.
English
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Balteau, Evelyne [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Moonen, Gustave [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Luxen, André [Université de Liège - ULg > Centre de Recherches du cyclotron - Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron > > >]
Lamy, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Brichant, Jean-François [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Maquet, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Département des sciences cliniques >]
Faymonville, Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
2009
NeuroImage
Elsevier Science
47
3
1047-54
Yes (verified by ORBi)
International
1053-8119
1095-9572
Orlando
FL
[en] The neural mechanisms underlying the antinociceptive effects of hypnosis still remain unclear. Using a parametric single-trial thulium-YAG laser fMRI paradigm, we assessed changes in brain activation and connectivity related to the hypnotic state as compared to normal wakefulness in 13 healthy volunteers. Behaviorally, a difference in subjective ratings was found between normal wakefulness and hypnotic state for both non-painful and painful intensity-matched stimuli applied to the left hand. In normal wakefulness, non-painful range stimuli activated brainstem, contralateral primary somatosensory (S1) and bilateral insular cortices. Painful stimuli activated additional areas encompassing thalamus, bilateral striatum, anterior cingulate (ACC), premotor and dorsolateral prefrontal cortices. In hypnosis, intensity-matched stimuli in both the non-painful and painful range failed to elicit any cerebral activation. The interaction analysis identified that contralateral thalamus, bilateral striatum and ACC activated more in normal wakefulness compared to hypnosis during painful versus non-painful stimulation. Finally, we demonstrated hypnosis-related increases in functional connectivity between S1 and distant anterior insular and prefrontal cortices, possibly reflecting top-down modulation.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - FNRS ; the European Commission ; the James McDonnell Foundation ; the Mind Science Foundation ; French Speaking Community Concerted Research Action ; Fondation Médicale Reine Elisabeth
http://hdl.handle.net/2268/27012
10.1016/j.neuroimage.2009.05.031
http://www.coma.ulg.ac.be/papers/hypnosis.html

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