Reference : Nonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematos...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/26992
Nonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
English
Clercx, Cécile mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux >]
Mc Entee, Kathleen mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Sémiologie et clinique médicale des petits animaux >]
Gilbert, S. [> > > >]
Michiels, L. [> > > >]
Snaps, Frédéric [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Imagerie médicale >]
Jacquinet, E. [> > > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Henroteaux, Marc mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Bernadina, W. E. [> > > >]
1999
Journal of the American Animal Hospital Association
35
3, May-Jun
220, 222, 224-8
Yes (verified by ORBi)
International
0587-2871
[en] A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies.
Researchers ; Professionals
http://hdl.handle.net/2268/26992

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