Epstein-Barr virus; Hodgkin's disease; in situ hybridization; immunohistochemistry
Abstract :
[en] The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70 % of cases and by latent membrane protein I (LMPI) immunohistochemistry in 58.4 % of cases. EBER positive cases were more frequent in extreme age clashes (< 15 and > 54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.
Disciplines :
Oncology
Author, co-author :
Korbi, S.
Trimeche, M.
Sriha, B.
Yacoubi, M. T.
Hmissa, S.
Mokni, M.
Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Rammeh, S.
Language :
French
Title :
Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia
Henle G., Henle W., Diehl V. (1968) Relation of Burkitt's tumor associated herpes-type virus to mononucleosis. Proc Natl Acad Sci USA 59:94-99.
Epstein M.A., Achong B.G., Barr Y.M. (1964) Virus particules in cultured lymphoblasts from Burkitt's lymphoma. Lancet 1:702-703.
Zur Hausen H., Schulte-Holthausen H., Klein G., Henle W., Henle G., Clifford P. (1970) Epstein-Barr virus DNA in biopsies of Burkitt's tumors and anaplastic carcinomas of the nasopharynx. Nature 228:1056.
Saemundsen A.K., Purtilo D.T., Sakamoto K., Sullivan J.L., Synnerholm A.C., Hanto D. (1981) Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridation. Cancer Res 41:4237-4242.
Ross R., Dworsky R., Paganini-Hill A., Levine A., Mack T. (1985) Non-Hodgkin's lymphomas in never married men in Los Angeles. Br J Cancer 52:785-787.
Weiss L., Strickler J.G., Warnke P.A., Purtilo D.T., Sklar J. (1987) Epstein-Barr virus-DNA, in tissues of Hodgkin's disease. Am J Pathol 129:86-91.
Harabuchi Y., Yamanaka N., Kataura A., Imai S., Kinoshita T., Mizuno F. (1990) Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. Lancet 335:128-130.
Hummel M., Anagnostopoulos I., Korbjuhn P., Stein H. (1995) Epstein-Barr virus in B-cell non Hodgkin's lymphomas: Unexpected infection patterns and different infection incidence in low and high grade types. J Pathol 175:263-271.
D'amore F., Johanson P., Houmand A., Weisenburger D.D., Mortensen L.S. (1996) Epstein-Barr virus genome in non-Hodgkin's lymphomas occurring in immunocomptent patients: Highest prevalence in nonlymphoblastic T-cell lymphoma and correlation with a poor prognosis. Blood 87:1045-1055.
De Bruin P.C., Jiwa N.M., Van der Valk, Van Heerde P., Gordijn R., Ossenkoppele G.J. (1993) Detection of Epstein-Barr virus nucleic acid sequences and protein in nodal T-cell lymphomas: Relation between latent membrane protein-1 positivity and clinical course. Histopathology 23:509-518.
Chan J.K., Yip T.T., Tsang W.Y., Poon Y.F., Wong C.S., Ma V.W. (1994) Specific association of Epstein-Barr virus with lymphoepithelial carcinoma among tumors and tumorlike lesions of the salivary gland. Arch Pathol Lab Med 118:994-997.
Butler A.E., Colby T.V., Weiss L., Lombard C. (1989) Lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol 13:632-639.
Shibata D., Tokunaga M., Uemura Y., Sato E., Tanaka S., Weiss L.M. (1991) Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Am J Pathol 139:469-474.
Yuen S.T., Chung L.P., Leung S.Y., Luk I.S., Chan S.Y., Ho J. (1994) In situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas. Am J Surg Pathol 18:1158-1163.
Ott G., Kirchner T., Muller-Hermelink H.K. (1994) Monoclonal Epstein-Barr virus genomes but lack of EBV-related protein expression in different types of gastric carcinoma. Histopathology 25:323-329.
Wang D., Liebowitz D., Kieff E. (1985) An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43:831-840.
Fahraeus R., Rymo L., Rhim J.S., Klein G. (1990) Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus. Nature 345:447-449.
Correa P., O'conor G.T. (1971) Epidemiologic patterns of Hodgkin's disease. Int J Cancer 8:192-201.
Glaser L., Lin R.J., Stewart S.L., Ambinder R.F., Jarrett R.F., Brousset P. (1997) A Epstein-Barr virus-associated Hodgkin's disease: Epidemiologic characteristics in international data. Int J Cancer 70:375-382.
Khan G., Norton A.J., Slavin G. (1993) Epstein-Barr virus in Hodgkin disease relation to age and subtype. Cancer 71:3124-3129.
Herbst H., Niedobitek G., Kneba M., Hummel M., Finn T., Anagnostopoulos I. (1990) High incidence of Epstein-Barr virus genomes in Hodgkin's disease. Am J Pathol 137:13-18.
Tomita Y., Ohsawa M., Kanno H., Hashimoto M., Ohnishi A., Nakanishi H. (1996) Epstein-Barr virus in Hodgkin's disease patients in Japan. Cancer 77:186-192.
Delsol G., Brousset P., Chittal S., Rigal-Huguet F. (1992) Correlation of the expression of Epstein-Barr virus-latent membrane protein and in situ Hybridization with biotinylated Barn HI-W probes in Hodgkin's disease. Am J Pathol 140:247-253.
Chang K.L., Albujar P.F., Chen Y.Y., Johnson R.M., Weiss L.M. (1993) High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin's disease occuring in Peru. Blood 81:496-501.
Ambinder R.F., Browning P.J., Lorenzana I., Leventhal B.G., Cosenza H., Mann R.B. (1993) Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 81:462-467.
Zarate-Osorno A., Roman L.N., Kingma D.W., Meneses-Garcia A., Jaffe E.S. (1995) Hodgkin's disease in Mexico. Prevalence of Epstein-Barr virus sequences and correlations with histologic subtype. Cancer 75:1360-1366.
Dimhofer S., Angeles-Angeles A., Ortiz-Hidalgo C., Reyes E., Gredler E., Krugmann J. (1999) High prevalence of a 30-base pair deletion in the Epstein-Barr virus (EBV) latent membrane protein 1 gene and of strain type B EBV in Mexican classical Hodgkin's disease and reactive lymphoid tissue. Human pathology 30:781-787.
Jarrett R.F., Gallagher A., Jones D.B., Alexander F.E., Krajewski A.S., Kelsey A. (1991) Detection of Epstein-Barr virus genomes in Hodgkin's disease: Relation to age. J Clin Pathol 44:844-848.
Anagnostopoulos I., Hummel M. (1996) Epstein-Barr virus in tumours. Histopathology 29:297-315.
Armstrong A.A., Alexander F.E., Cartwright R., Angus B., Krajewski A.S., Wright D.H. (1998) Epstein-Barr virus and Hodgkin's disease: Further evidence for the three disease hypothesis. Leukemia 12:1272-1276.
Murray P.G., Billingham L.J., Hassen H.T., Flavell J.R., Nelson P.N., Scott K. (1999) Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease. Blood 94:442-447.
Morente M.M., Piris M.A., Abraira V., Acevedo A., Aguilera B., Bellas C. (1997) Adverse clinical outcome in Hodgkin's disease is associated with loss of retinoblastoma protein expression, high Ki67 proliferation index, and absence of Epstein-Barr virus-latent membrane protein 1 expression. Blood 90:2429-2436.
Naresh K.N., Johnson J., Srinivas V., Soman C.S., Saikia T., Advani S.H. (2000) Epstein-Barr virus association in classical Hodgkin's disease provides survival advantage to patients and correlates with high expression of proliferation markers in Reed-Sternberg cells. Ann Oncol 11:91-96.
Glavina-Durdov M., Jakic-Razumovic J., Capkun V., Murray P. (2001) Assessment of the prognostic impact of the Epstein-Barr virus-encoded latent membrane protein 1 expression in Hodgkin's disease. Br J Cancer 84:1227-1234.
Clarke C.A., Glaser S.L., Dorfman R.F., Mann R., Diguiseppe J.A., Prehn A. (2001) Epstein-Barr Virus and survival after Hodgkin disease in a population-based series of women. Cancer 91:1579-1587.
Herbest H., Raff T., Stein H. (1996) Phenotypic modulation of Hodgkin and Reed-Sternberg with Epstein-Barr virus. J Pathol 179:54-59.
Armstrong A.A., Gallagher A., Krajewski A.S., Jones D.B., Wilkins B.S., Onions D.E. (1992) The expression of the EBV Latent Membrane Protein (LMPI) is independent of CD23 and bc12 in Reed-Sternberg cells in Hodgkin's disease. Histopathology 21:72-73.
Sandvej K.B., Hamilton-Dutoit S.J., Pallesen G. (1993) Influence of Epstein-Barr virus encoded latent membrane protein 1 on the expression of CD23 antigen, ICAM-1 and LFA-3 in Hodgkin and Reed-Sternberg cells. A morphometric analysis. Leuk Lymphoma 9:95-101.
