Reference : The expression of Clostridium perfringens consensus beta2 toxin is associated with bo...
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/26816
The expression of Clostridium perfringens consensus beta2 toxin is associated with bovine enterotoxaemia syndrome
English
Lebrun, Maud [Université de Liège - ULg > Département des maladies infectieuses et parasitaires >]
Filée, Patrice [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Mousset, Bénédicte mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Galleni, Moreno mailto [Université de Liège - ULg > Département des sciences de la vie > Macromolécules biologiques >]
Mainil, Jacques mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes >]
Linden, Annick mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage >]
2007
Veterinary Microbiology
Elsevier Science
120
1-2
151-157
Yes (verified by ORBi)
International
0378-1135
Amsterdam
The Netherlands
[en] Clostridium perfringens ; bovine enterotoxaemia ; beta2-toxin ; atypic allele ; expression
[en] Clostridium perfringens has been implicated in a broad array of enteric infections including the fatal haemorrhagic enteritis/enterotoxaemia syndrome in cattle. The beta2 toxin (CPB2), encoded by cpb2, is suspected to be implicated in this syndrome. However, among C. perfringens isolates from cattle suspected of clostridial disease, an atypical allele was recently found to predominate at the cpb2 locus and atypical corresponding CPB2 proteins were shown to be poorly expressed, thus arguing against a biologically significant role of the beta2 toxin in clostridial diseases in cattle. This study compared genotype and phenotype of the beta2 toxin between C. perfringens isolates from a group of healthy calves (n = 14, 87 isolates) and from a group of enterotoxaemic calves (n = 8,41 isolates). PCR results revealed the exclusive presence of the typical "consensus" cpb2 in the enterotoxaernic group. Western blot analysis demonstrated that the typical variant of CPB2 was often expressed in isolates from enterotoxaemic calves (43.9%) and infrequently in isolates from healthy cattle (6.9%). These data suggest that the typical variant of the CPB2 toxin may play a role in the pathogenesis of cattle enterotoxaemia. (c) 2006 Elsevier B.V. All rights reserved.
Researchers ; Professionals
http://hdl.handle.net/2268/26816
also: http://hdl.handle.net/2268/72370
10.1016/j.vetmic.2006.10.020

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
2007-The expression of Clostridium perfringens consensus beta2 toxin.pdfNo commentaryPublisher postprint196.6 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.