Reference : Surgical management of amiodarone-associated thyrotoxicosis: too risky or too effective?
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Surgery
http://hdl.handle.net/2268/26749
Surgical management of amiodarone-associated thyrotoxicosis: too risky or too effective?
English
Hamoir, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Meurisse, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Defechereux, Thierry [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Joris, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Vivario, Janine [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Hennen, Georges [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
1998
World Journal of Surgery
Springer Verlag
22
6
537-42; discussion 542-3
Yes (verified by ORBi)
International
0364-2313
New York
NY
[en] Aged ; Aged, 80 and over ; Amiodarone/adverse effects ; Anti-Arrhythmia Agents/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Thyroidectomy ; Thyrotoxicosis/chemically induced/surgery ; Treatment Outcome
[en] Amiodarone-associated thyrotoxicosis, often clinically mild and resolutive after amiodarone discontinuation or under medical therapy, is sometimes drug unresponsive and not uncommonly follows a dramatic, even fatal course. Therefore, we considered a surgical solution in 15 severely amiodarone-associated thyrotoxic patients. Twelve men and three women (mean age 68 years, range 50-84 years) underwent radical thyroidectomy for clinical and biologically proved amiodarone-associated thyrotoxicosis. In six surgery was the first-line therapeutic option. In the other nine thyroidectomy seemed unavoidable considering the unresponsiveness to medical therapy and rapid deterioration of the patients' clinical condition, with life-threatening cardiac failure in three. In every patient surgery was conducted without immediate or delayed complications. Total thyroidectomy proved uniformly, definitively, and rapidly effective in controlling thyrotoxicosis in all patients, with a spectacular reversal of cardiac failure in the three most critical cases. Surgery was beneficial to our 15 patients and undoubtedly life-saving in the three most worrying cases. These results suggest that thyroidectomy should be more liberally regarded as an interesting alternative to conventional, but unpredictably effective, medical therapies.
http://hdl.handle.net/2268/26749

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