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| Reference : Regulation of growth hormone messenger RNA |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/26698 | |||
| Regulation of growth hormone messenger RNA | |
| English | |
Martial, Joseph  [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >] | |
| Seeburg, P. H. [> > > >] | |
| Matulich, D. T. [> > > >] | |
| Goodman, H. M. [> > > >] | |
| Baxter, J. D. [> > > >] | |
| 1979 | |
| Monographs on Endocrinology | |
| Springer Verlag | |
| 12 | |
| 279-89 | |
| 0077-1015 | |
| Berlin | |
| Germany | |
| [en] Animals ; Cell Line ; Cell Nucleus/metabolism ; Dexamethasone/metabolism/*pharmacology ; Growth Hormone/*biosynthesis ; Hydrocortisone/metabolism ; Kinetics ; Nucleic Acid Hybridization ; Pituitary Gland ; *Protein Biosynthesis/drug effects ; RNA, Messenger/*metabolism ; Rats ; Receptors, Glucocorticoid/*metabolism ; Receptors, Steroid/*metabolism | |
| [en] In cultured rat pituitary cells, glucocorticoids regulate growth hormone production by modulating the number of growth hormone messenger RNA molecules. The effect is quite specific, since only a few other mRNAs are affected by the hormones. This response is demonstrated by assays involving cell-free mRNA translation and cDNA-RNA hybridization. Furthermore, the inducibility by the glucocorticoids is regulated by at least one other class of hormones, thyroid hormone. Thus, this system serves as a model for studying not only the glucocorticoid regulation of specific mRNA, but also the control of this regulation by other factors in the target tissue. | |
| http://hdl.handle.net/2268/26698 | |
| 1979/01/01 |
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