Reference : Regulation of growth hormone messenger RNA
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Regulation of growth hormone messenger RNA
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Seeburg, P. H. [> > > >]
Matulich, D. T. [> > > >]
Goodman, H. M. [> > > >]
Baxter, J. D. [> > > >]
Monographs on Endocrinology
Springer Verlag
Yes (verified by ORBi)
[en] Animals ; Cell Line ; Cell Nucleus/metabolism ; Dexamethasone/metabolism/*pharmacology ; Growth Hormone/*biosynthesis ; Hydrocortisone/metabolism ; Kinetics ; Nucleic Acid Hybridization ; Pituitary Gland ; *Protein Biosynthesis/drug effects ; RNA, Messenger/*metabolism ; Rats ; Receptors, Glucocorticoid/*metabolism ; Receptors, Steroid/*metabolism
[en] In cultured rat pituitary cells, glucocorticoids regulate growth hormone production by modulating the number of growth hormone messenger RNA molecules. The effect is quite specific, since only a few other mRNAs are affected by the hormones. This response is demonstrated by assays involving cell-free mRNA translation and cDNA-RNA hybridization. Furthermore, the inducibility by the glucocorticoids is regulated by at least one other class of hormones, thyroid hormone. Thus, this system serves as a model for studying not only the glucocorticoid regulation of specific mRNA, but also the control of this regulation by other factors in the target tissue.

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