|Reference : Regulation of growth hormone messenger RNA|
|Scientific journals : Article|
|Life sciences : Biochemistry, biophysics & molecular biology|
|Regulation of growth hormone messenger RNA|
|Martial, Joseph [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]|
|Seeburg, P. H. [> > > >]|
|Matulich, D. T. [> > > >]|
|Goodman, H. M. [> > > >]|
|Baxter, J. D. [> > > >]|
|Monographs on Endocrinology|
|[en] Animals ; Cell Line ; Cell Nucleus/metabolism ; Dexamethasone/metabolism/*pharmacology ; Growth Hormone/*biosynthesis ; Hydrocortisone/metabolism ; Kinetics ; Nucleic Acid Hybridization ; Pituitary Gland ; *Protein Biosynthesis/drug effects ; RNA, Messenger/*metabolism ; Rats ; Receptors, Glucocorticoid/*metabolism ; Receptors, Steroid/*metabolism|
|[en] In cultured rat pituitary cells, glucocorticoids regulate growth hormone production by modulating the number of growth hormone messenger RNA molecules. The effect is quite specific, since only a few other mRNAs are affected by the hormones. This response is demonstrated by assays involving cell-free mRNA translation and cDNA-RNA hybridization. Furthermore, the inducibility by the glucocorticoids is regulated by at least one other class of hormones, thyroid hormone. Thus, this system serves as a model for studying not only the glucocorticoid regulation of specific mRNA, but also the control of this regulation by other factors in the target tissue.|
There is no file associated with this reference.
All documents in ORBi are protected by a user license.