Reference : The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
Scientific journals : Article
Life sciences : Genetics & genetic processes
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/26588
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
English
De Jager, P. L. [> > > >]
Franchimont, D. [> > > >]
Waliszewska, A. [> > > >]
Bitton, A. [> > > >]
Cohen, Atika [Université de Liège - ULg > > UER Opérations >]
Langelier, D. [> > > >]
Belaiche, Jacques [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie]
Vermeire, S. [> > > >]
Farwell, L. [> > > >]
Goris, A. [> > > >]
Libioulle, Cécile [Université de Liège - ULg > > Génétique >]
Jani, N. [> > > >]
Dassopoulos, T. [> > > >]
Bromfield, G. P. [> > > >]
Dubois, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Cho, J. H. [> > > >]
Brant, S. R. [> > > >]
Duerr, R. H. [> > > >]
Yang, H. [> > > >]
Rotter, J. I. [> > > >]
Silverberg, M. S. [> > > >]
Steinhart, A. H. [> > > >]
Daly, M. J. [> > > >]
Podolsky, D. K. [> > > >]
Louis, Edouard mailto [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie >]
Hafler, D. A. [> > > >]
Rioux, J. D. [> > > >]
Jul-2007
Genes and Immunity
Nature Publishing Group
8
5
387-397
Yes (verified by ORBi)
International
1466-4879
London
[en] Toll-like receptor ; inflammatory bowel disease ; NFKB1 ; TLR4 ; TIRAP
[en] The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15 - 1.48; P = 0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16 - 1.54; P = 0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04 - 1.30; P = 0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway - in this case, TLR4 and its signaling molecule TIRAP - plays a role in susceptibility to IBD.
http://hdl.handle.net/2268/26588

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