Reference : Matrix metalloproteinase-9 contributes to choroidal neovascularization
Scientific journals : Article
Human health sciences : Ophthalmology
http://hdl.handle.net/2268/26536
Matrix metalloproteinase-9 contributes to choroidal neovascularization
English
Lambert, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Munaut, Carine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Jost, M. [> > > >]
Werb, Z. [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Rakic, Jean-Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Ophtalmologie >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Oct-2002
American Journal of Pathology
Amer Soc Investigative Pathology, Inc
161
4
1247-1253
Yes (verified by ORBi)
International
0002-9440
Bethesda
[en] age-related macular degeneration ; MMP-9 ; angiogenesis
[en] Age-related macular degeneration (AMD) is the primary cause of irreversible photoreceptors loss in adult patients and current therapies are limited. Increased levels of matrix metalloproteinases (MMPs) have been documented in neovascularization of severe ocular pathologies such as AMD and proliferative diabetic retinopathy. We report here that MMP-9 (gelatinase B) expression is induced and temporally regulated in the course of experimental choroidal neovascularization. We used transgenic mice expressing beta-galactosidase reporter gene under the dependence of MMP-9 promoter and RT-PCR analysis on choroidal neovascular structures microdissected from serial sections by laser pressure catapulting to show that MMP-9 expression is up-regulated concomitantly with the appearance of inflammatory cells in the subretinal lesion. In mice deficient in MMP-9 expression the development of choroidal neovascularization induced by laser photocoagulation still occurred, but at a reduced level.
http://hdl.handle.net/2268/26536
http://ajp.amjpathol.org/cgi/content/full/161/4/1247

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