|Reference : Effects of Peep on Systemic Venous Capacitance|
|Scientific journals : Article|
|Human health sciences : General & internal medicine|
|Effects of Peep on Systemic Venous Capacitance|
|Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]|
|Detry, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]|
|D'Orio, Vincenzo [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]|
|Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]|
|Fossion, Anny [Université de Liège - ULg > > Relations académiques et scientifiques (Psycho et sc.éduc.) >]|
|Gérard, Paul [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]|
|Marcelle, Roland [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]|
|Limet, Raymond [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique]|
|Archives of Physiology & Biochemistry|
|[en] The aim of the present study was to determine effects of positive end expiratory pressure (PEEP) application on peripheral venous capacitance and relate them to concomitant central hemodynamic disturbances. The venous volume-pressure (V/P) relationships were studied in 6 intact anesthetized pigs to describe the effects of PEEP on systemic venous compliance (computed as the slope of the V/P relationship) and unstressed volume (referred to as the extrapolated volume intercept). Cardiac volumes as well as partitioning of circulating blood volume between central (ITBV) and peripheral (PBV) compartments were assessed by thermo-dye dilution techniques. During a 15 cm H2O PEEP application, venous compliance was reduced by 48%, while unstressed volume was increased by 25% and peripheral blood pooling increased from 63 to 74%. As a result, left heart and right ventricular end diastolic volumes were decreased by 8% and by 44%, respectively. It is concluded that increased venous unstressed volume and reduced compliance depicted the distension of the venous tree secondary to PEEP which acted as an impediment to venous return. As a consequence, cardiac output was reduced because of decreased preload.|
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