Reference : Dendritic Cells: More Than Just Adaptive Immunity Inducers?
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/26424
Dendritic Cells: More Than Just Adaptive Immunity Inducers?
English
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Boniver, Jacques mailto [Université de Liège - ULg > > Anatomie pathologique >]
Hubert, Pascale mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
2007
Current Immunology Reviews
Bentham Science Publishers Ltd.
2
17-22
Yes (verified by ORBi)
International
1573-3955
[en] immunity ; Innate lymphocye ; Natural killer ; dendritic cells ; gd T cells ; ag-presenting cells
[en] Dendritic cells (DC) are well known for their capacity to induce immune responses and there is also accumulating evidence of their ability to interact with various cell types of the innate system, such as NK, NKT or TCR gamma-delta cells. These interactions are bi-directional, mediated by soluble or cell surface molecules and have been mainly described in the context of immune responses to infectious agents and tumors.
NK, NKT or TCR gamma-delta cells induce the maturation of DC, as shown by the increased expression of CD86, IL12 production and priming of T cell responses. On the other hand, mature DC have the ability to activate NK, NKT or TCR gamma-delta cells for sustained innate immune responses and activated NK cells may kill immature DC. In addition, DC and NK or TCR gamma-delta cells share similar functions such as cytotoxic and antitumor activity, interferon production and antigen presentation capacity.
Fonds Léon Fredericq ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Centre Anti-Cancereux près l’Université de Liège
Researchers ; Students ; General public
http://hdl.handle.net/2268/26424

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