Reference : Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uter...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Oncology
http://hdl.handle.net/2268/26242
Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix
English
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Herman, Ludivine [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Kholod, Natalia [> > > >]
Caberg, Jean-Hubert [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Herfs, Michael mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Boniver, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Hubert, Pascale mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
2007
Molecular & Cellular Endocrinology
North Holland Publishing Company
264
1-2
1-5
Yes (verified by ORBi)
International
0303-7207
Amsterdam
The Netherlands
[en] Carcinoma, Squamous Cell/immunology/metabolism/pathology/virology ; Cell Transformation, Viral/immunology ; Cervix Uteri/immunology/metabolism/pathology/virology ; Female ; Gene Expression Regulation, Viral ; Gonadal Steroid Hormones/metabolism ; Humans ; Metaplasia ; Tumor Virus Infections/immunology/metabolism/pathology ; Uterine Cervical Neoplasms/immunology/metabolism/pathology/virology
[en] If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.
IAP (interuniversityattractionpole) network(P5/31) ; Centre de Recherches Interuniversitaires en Vaccinologie GSK and WalloonRegion ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers ; Students
http://hdl.handle.net/2268/26242
10.1016/j.mce.2006.10.014

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