[en] In the present study, P300 has been recorded in 26 subjects (15 women) 1 month after an aggression without organic complications. Among our sample, 16 subjects fulfilled DSM-III-R criteria for posttraumatic stress disorder (PTSD) and 10 did not. P300 amplitude was significantly lower in the 16 PTSD subjects as compared to the 10 subjects without PTSD. This study supports information processing disturbances in PTSD.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Author, co-author :
Charles, Gérard; Bristol Myers Squibb Pharmaceutical Research Institute
Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Ansseau, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, (ed 3). Washington, Amnerican Psychiatric Association, 1987.
Blanchard EB, Kolb LC, Prins A: Psychophy-siological responses in the diagnosis of post-traumatic stress disorder in Vietnam veterans. J Nerv Ment Dis 1991:179:97-101.
Paige SR. Reid GM, Allen MG: Psychophysio-logical correlates of posttraumatic stress disorder in Vietnam veterans. Biol Psychiatry 1991: 27:419-430.
Donchin E, Coles MHG: Is the P300 component a manifestation of context updating? Behav Brain Sci 1988;11:357-374.
Blackwood DHR Muir WJ: Cognitive brain potentials and their application. Br J Psychiatry' 1990:157:96-101.
Chemtob C, Roitblat HL, Hamada RS: A cognitive action theory of post-traumatic stress disorder. J Anxiety Disord 1988:2:253-275.
McFarlane AC, Weber DL, Clark CR: Abnormal stimulus processing in posttraumatic stress disorder. Biol Psychiatry 1993:34:311-320.
Endieott J. Spitzer RL: A diagnostic interview: The schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978:35: 835-844.
Horowitz MJ: Stress response syndromes: A review of posttraumatic and adjustment disorders. Hosp Community Psychiatry 1986:37: 241-249.
